Leipzig will come into the match on the back of a disappointing one-nil defeat to current Bundesliga leaders VFL Wolfsburg just before the International break.
The result meant that Leipzig find themselves in a disappointing tenth position in the league table, and with only two points the difference between them and FC Ausburg in 17th as well as matches in the champions league coming up, Leipzig will be hoping for a confidence-building win on Saturday evening.
In contrast, Bayern will come in into the match off the back of an impressive five goal rout against Hertha Berlin, just before the International break.
It means Bayern find themselves sitting in third place in the league, two points behind Wolfsburg in first and under pressure from SC Freiburg level on points in fourth all the way down to Hoffenheim in ninth who are three points behind them. Like Leipzig, Bayern will be hoping for a confidence-boosting win with matches in the champions league starting next week.
Jesse Marsch has only got two major injury concerns going into the match with defenders Marcel Halstenberg and Marcel Sarrachi both set to miss out due to injury. Marsch could also give a debut to 18-year-old Ilaix Moriba after his deadline day move from Barcelona.
Meanwhile, Julian Nagelsman also has two injury concerns with Alphonso Davies and Corentin Tolisso set to miss out, while Thomas Muller is expected to be fully fit again having not played for Germany during the international break due to a minor injury.
RB Leipzig: Gulaschi, Klosterman, Orban, Simakan, Angelino, Adams, Moriba, Soboszlai, Olmo, Nkunku, Silva
Bayern Munich: Neuer, Stanisic, Upamecano, Sule, Pavard, Kimmich, Goretzka, Gnabry, Musiala, Muller, Lewandoski.
Players to watch
After signing for Leipzig from their sister club RB Salzburg last January, many people were expecting him to have an instant impact, however, he got a serious injury and as a result missed the second half of last season, as well as the Euro's for Hungary in the summer.
Having recovered from injury and having a full pre-season due to him not being involved at the Euro's this summer Soboszlai has started this season like a house on fire.
Soboszlai has scored two goals in three matches in the Bundesliga so far this season as well as scoring in the first round of the DFB Pokal against SV Sandhausen. It means he will be the main threat for Leipzig and will try and breach the Bayern defense.
Robert Lewandowski has started this season with the intent to try and beat his record-breaking 41 goals last season. So far from three matches played he has scored five times including a hat-trick during Bayern's five-goal rout of Hertha.
He continued his form through the international break scoring three goals within the space of two matches as well as providing the assist for Damian Szymanski last-minute equalizer against England on Wednesday night.
With his hot form in front of goal, Bayern will be hoping that Lewandowski can help steer them to victory.
Last time out
The last time these two faced each other was last December in what was a frantic and enthralling encounter.
Leipzig started the match brightly and almost took an early lead after Marcel Sabitzer hit the crossbar in the third minute following a corner from the left-hand side.
Leipzig's early pressure eventually paid off when they scored the first goal of the match in the 19th minute. Emil Forsberg received the ball after an attack from Bayern broke down and slid the ball through to Christopher Nkunku who calmly went around Manuel Neuer and rolled the ball into the back of the net.
After a sustained period of pressure, Bayern finally got the equalizer in the 30th minute when teenage wonderkid Jamal Musiala found the bottom corner of the goal from outside the box following a one-two with Kingsley Coman on the left-hand side.
Bayern then took the lead for the first time in the match just four minutes later. This time it was Thomas Muller with the goal. Muller made a dangerous run off the ball and was found by Coman before clinically sending his shot into the goal.
But their lead only lasted two minutes because Leipzig pulled a goal back to make the match all square again. Amadou Haidara passed the ball to Justin Kulivert into the right-hand side of the box before he unleashes a thunderous strike into the bottom left-hand corner beating Neuer.
During the second half, the craziness continued. Leipzig retook the lead in the 48th minute when Forsberg in acres of space got on the end of a cross from Angelino to head the ball into the Bayern net.
However, it was not to be for Leipzig as Bayern got the equalizer in the 75th minute with Muller again getting the goal. Coman dribbled past a few Leipzig defenders on the right-hand side of the pitch before whipping in a delicious ball that Muller headed authoritatively into the Leipzig goal.
Fans in the UK will be able to catch the game at 5:30 pm on Saturday on Sky Sports while fans in the US, can watch the match on ESPN+.