Bayern come into the match off the back of a brilliant and astounding five goal to one victory over Bayer Leverkusen. It means they find themselves top of the table just one point ahead of Borussia Dortmund.
Bayern will know that they have to win on Saturday afternoon to remain top of the table as if they don't they will potentially be leapfrogged by Dortmund who have what looks like to be an easy match against Arminia Bielefeld.
Similar to Bayern, Hoffenheim will come into this match off the back of a five-goal thrashing of FC Köln . It means they find themselves sitting in ninth place four points off a European place.
If Hoffenheim are able to continue where they left off against Köln and beat Bayern not only would it be a serious dent in Bayern's season, but it would also give them the confidence that they can beat anyone. In addition if Union Berlin slip up against VFB Stuttgart Hoffenheim would only be two points behind them.
Julian Nagelsman has got several major injury concerns ahead of the match. Alphonso Davies could miss out following his thigh injury he sustained on Wednesday night. Leon Goretzka could also miss out as he tries to recover from a cold.
Hoffenheim boss Sebastian Hoeneß has got four injury concerns ahead of the match. Ermin Bičakčić and wing back Pavel Kadeřábek expected to miss out while Benjamin Hübner and teenager Marco John are also out due to injury.
Bayern Munich: Neuer, Pavard, Upamecano, Süle, Hernandez, Kimmich, Sabitzer, Gnabry, Muller, Lewandowski
Hoffenheim: Baumann, Posch, Grillitsch, Richards, Akpoguma, Samassekou, Geiger, Raum, Baumgartlinger, Bebou, Kramaric
Players to watch
So far this season Sane has got two goals and three assists in eight matches as well as starting most of their matches. His most recent goal exploits came on Wednesday night as he grabbed a brace to help Bayern cruise to victory over SL Benfica.
Bayern will be hoping Sane can get on the scoresheet again at the weekend.
Hoffenheim have found it difficult this season to score goals with not a single player having scored more than three so far, however the one bright spark is croation playmaker Andrej Kramarić who has got six assists to his name.
Although he is not an out-and-out goalscorer everything creative in the attacking third for Hoffenheim goes through him. So in order for Hoffenheim to have any chance they will need Kramarić to at his best and try and unlock the Bayern defence.
Last time out
The last time these two faced each other was last January where Bayern demolished Hoffenheim by four goals to one.
Hoffenheim started the match brightly and got an early chance in the seventh minute, the brilliantly breached they Bayern defence through the middle and forced Manuel Neuer into a good save.
Bayern then hit the post in the 15th minute, Kingsley Coman did brilliantly on the left hand side of the pitch before crossing the ball to the back post however Thomas Muller chipped shot ricoched off the crossbar.
Bayern got a second just before halftime. Robert Lewandowski controlled the ball brilliantly in the Hoffenheim penalty box before laying it off to Muller who's shot from outside the box found the back of the net.
However Hoffenheim responded instantly pulling a goal back with Kramaric getting on the score sheet to ensure Hoffenheim were only one goal down going into half time.
Bayern restored their two-goal lead in the 57th minute when Lewandowski got his name on the scoresheet. Coman yet again did brilliant work before passing the ball to Lewandowski who hammered it into the net.
Bayern got their fourth and last goal in 62nd minute. Serg Gnabry decided to get in on the goal scoring action. Coman again did magical work with the ball before giving it to Gnabry who like his teammates clinically dispatched his attempt on goal.
How to watch
Unfortunately the match will not be shown live in the UK However fans in America can catch the game on ESPN +