The Blues will be hoping to get off to a perfect start with a win against their opposition.
Monday night’s game will also be the first chance to see Kai Havertz in action since his arrival from Bayer Leverkusen.
The two sides recently met in a pre-season friendly at The American Express Community Stadium, which ended in a 1-1 draw.
With the new season fast approaching, VAVEL Chelsea looks into the history between the two sides.
Chelsea and Brighton have faced each other 14 times, with the Blues winning 11 of those fixtures.
The first meeting between the two sides came in 1933 when Brighton won 2-1 in the FA Cup.
Arthur Attwood and Ernie Wilson were on target for the Seagulls, with George Barber getting Chelsea’s only goal of the game.
This has been Brighton’s only win against Chelsea in all competitions.
In the 1983/84 season, the two teams met for their first competitive league games against each other, with Chelsea winning both matches in Division Two.
On Boxing Day in 2017, 28 years after their previous clash, the Blues faced Brighton at Stamford Bridge in the Premier League.
The hosts were once again victorious, courtesy of goals from Alvaro Morata and Marcos Alonso.
Just under a month later, Chelsea thrashed the south coast side 4-0 thanks to an Eden Hazard brace and strikes from Willian and Victor Moses.
In 2019, Ruben Loftus-Cheek was the star of the show as he scored and assisted in a 3-0 win over the Seagulls at the Bridge.
Brighton were able to claim their first point against the Blues in 11 attempts with a 1-1 draw at home on New Year’s Day earlier this year.
Blues captain Cesar Azpilicueta put the visitors ahead in the first half, but Alireza Jahanbakhsh’s spectacular overhead kick secured a vital point for the hosts.
Overall, Chelsea have scored 28 times and only conceded six goals against Brighton in all competitions over the years.
With the additions that they have made in the transfer window, the Blues are undoubtedly the favourites to win on Monday night.
It is now up to Frank Lampard and his squad to continue their fantastic record against Brighton and begin the new season with a win.