Mark Bonner's Cambridge are in impressive league form, having won three of their previous four and currently sitting one point clear at the head of the table. They will be defensively weakened however, as Harry Darling made the move to MK Dons.
Bradford however have immensely strengthened, having already made six signings so far this window under interim manager Mark Trueman.
Bonner admitted prior to the match that he was unsure what to expect of the Bantams, saying:
"They have also added six players so far to the squad, so it will be a bit of a different challenge to last time.
"But it’s a game we’re looking forward to and we need to carry on building on the good run of form we’ve just had.”
The Bantams will be lacking match fitness, having not played a game so far this calendar year, but also have a few players unavailable due to injuries.
Trueman confirmed that Harry Pritchard (back) would be unavailable, whilst Bryce Hossanah, Reece Staunton, Zeli Ismail and club captain Richard O'Donnell are all long-term absentees.
Mitov; Knoyle, Cundy, Taylor, Dunk, Hannant, May, Digby, Hoolahan, Mullin, Knibbs.
Hornby, Foulds, P O'Connor, A O'Connor, Wood, Sutton, Watt, Stevens, Novak, Clarke, Rowe.
Ones to watch
One man who has been in scintillating form this season is striker Paul Mullin.
The 26-year-old has been pivotal in Cambridge's outstanding season, having scored 18 goals and currently leading as the league's top scorer. The U's best transfer business of January is holding onto Mullin, as he could be a big part of leading Bonner's side to promotion.
Having signed from divisional rival Oldham Athletic during the week, Rowe will look to hit the ground running at his new club.
The prolific forward has had a successful season at the Latics before switching to City, and will look to carry his good form into a rejuvenated Bantams side.
Trueman has already masterminded a victory over Cambridge, thanks to a goal of the season contender from Pritchard. The inside forward chested down the ball before firing in on the half volley, to prompt the three points back in December for the Bantams.
The match is available on iFollow via Cambridge or Bradford's respective club websites, with match passes at £10 for those in the United Kingdom.