Ahead of the game, VAVEL take a look back at three memorable Wolves wins over the Whites at Molineux in years gone by.
Wolves 2-1 Leeds, 8 May 1972
One of the most famous games in Molineux's 132-year history came on the last day of the 1971-72 season, as Bill McGarry's Wolves denied Leeds their second First Division title.
UEFA Cup finalists Wolves had other ideas. Defender Frank Munro opened the scoring in the first half, before Derek Dougan doubled Wanderers' lead in the 67th minute.
Leeds' talismanic captain Billy Bremner pulled a goal back late on, but his side's dreams of a first ever league and cup double were dashed as Derby won the title for the first time.
Wolves 4-3 Leeds, 6 April 2015
Newly-promoted Wolves moved into the Championship play-off places as they defeated Leeds in a rollercoaster game on Easter Monday in 2015.
The Whites, who sat in 14th in the Championship, took the lead against their top-six chasing opponents when Charlie Taylor capitalised on a poor Kevin McDonald pass to prod home in front of the South Bank.
The lead lasted just eight minutes as Nouha Dicko finished from a near-impossible angle to equalise, before Wolves' number 40 picked up his second with a brilliant first-time finish past Marco Silvestri in first-half stoppage time.
Benik Afobe prodded home from close range after the interval to make it 3-1 as Wolves seemed to be heading for a straightforward three points, but a communication breakdown between Danny Batth and Carl Ikeme lead to the Wolves captain putting through his own net to reduce the deficit to one.
Alex Mowatt finished brilliantly into the top corner from range to draw Neil Redfearn's side level which looked to have snatched an unlikely point for Leeds, but Dave Edwards glanced home McDonald's brilliant cross with two minutes left to send Molineux into pandemonium and Wolves into the top six.
Wolves 4-1 Leeds, 22 November 2017
Wolves opened a four-point gap at the top of the Championship table as they eased aside Leeds' ten men in 2017.
Nuno's side took the lead with a quarter of an hour gone, as future Leeds left-back Barry Douglas fired a brilliant free-kick into the top corner, before Ivan Cavaleiro doubled Wolves' advantage after finishing a brilliant passing move.
Leeds halved the deficit three minutes after half-time through a brilliant Gjanni Alioski volley, but Ronaldo Vieira's second yellow card on the hour mark ended any hope of a Leeds comeback.
Diogo Jota clipped the ball over former Wolves keeper Andy Lonergan for Wanderers' third, before Helder Costa scored his first goal after a long-term injury from the penalty spot to earn Nuno's side's ninth win in 11 games.