A win would be a welcome boost for Nathan Jones' men - especially at home too, as the last seven home matches have ended as draws. The last home game for Luton was a 3-3 draw with Swansea, an albeit disappointing three points lost courtesy of a late Joel Piroe strike.
The visitors Coventry could make potential victory a challenging task though, as they look to continue a run of form that sees them four games unbeaten. The Sky Blues previous game was a comfortable 3-0 win against newly promoted strugglers Peterborough United and this season they've built up a reputation as the surprise package in the league.
Coventry's form is even better considering they finished 16th last term. Although a greatly competitive side under Mark Robins, Nathan Jones' Luton have faired relatively well against Coventry in recent times - in fact they are unbeaten in their last five league meetings.
A win against their 16th placed opponents would be Coventry's first away league win against Luton since October 2017. They arrive in Bedfordshire in good stead, as since the start of April - only Bournemouth (39) have won more Championship points than Coventry (35).
On the contrary, a win for the home side would be their first taste victory since a 1-0 win away to Barnsley back on the 17th of August.
Never one to pull any punches, Nathan Jones has suggested changes might be coming. He was quoted after the Bournemouth game: "Something has to change, whether that's personnel, whether that's tactics, something has to change, and then we have to be clinical."
He could perhaps be giving a nod to the chances missed against Bournemouth - the tale of the game was really that of Luton missing the finished product, with the table toppers taking advantage. From this, aforementioned changes might be coming in attack.
Missing a crucial sitter on Saturday, Elijah Adebayo's confidence may be rocked. His place in the side could be in jeopardy and Jones may opt for the more experienced Cameron Jerome.
New signing Elliot Thorpe may get his first start tomorrow evening. The 20-year-old signed for the Hatters last week and even travelled to the south coast at the weekend with the squad.
Pelly Ruddock Mpanzu may still be in doubt with the knock he picked up in training last week that saw him out of the team on Saturday.
Also, Chelsea loan signing Jake Clarke-Salter could continue in the side. The centre back was forced off just after an hour at The Den after a clash of heads against Millwall. Now recovered from an alleged concussion, there is a chance that Mark Robins could call the 24-year-old into action again. He played 73 minutes against Peterborough on Saturday.
Liam Kelly could see more minutes against Luton after slowly filtering back into first team action. The skipper suffered a late season knee ligament injury at Stoke and might well have been closer to a return to full fitness had he not been struck down with Covid this summer. He has been back in training and playing with the u23s - even coming on for the last ten minutes against Peterborough.
Luton Town: Sluga; Bree, Lockyer, Burke, Naismith (C), Bell, Lansbury, Berry, Clark, Jerome, Cornick.
Coventry City: Moore, Hyam, McFadzean, Clarke-Salter, Kane, Hamer, Kelly (C), Maatsen, O'Hare, Gyokeres, Waghorn.
Ones to watch
Swedish striker Viktor Gyokeres has rebooted his career at Coventry this season. He was at the Sky Blues on loan last season but struggled to find the net and life in the second division as the team trundled to 16th place.
However, the former Brighton man came back for another go and his form this term has made the bleak three goals in 19 games a thing of the past. In nine games so far this season, Gyokeres has notched an impressive seven times.
These goals are valuable to Robins' men and translate into points. No Championship player's goals have been worth more points to their team than Gyokeres with seven points decided by the forward's goal scoring exploits.
A player who could make all the difference for Luton Town on Wednesday evening could be Harry Cornick. The winger was one of few good things for the Hatters and his positive play created big (albeit missed) chances.
A fast and direct runner, his work rate down the flanks has always been impressive. Hopefully for Luton, the players around him will raise their game and utilise his supply - in a manner not replicating Saturday's dismal attempts.
So far this season, the 26-year-old has two goals to his name - but the stats shouldn't fully imply the right winger's influence on Luton's attack. He is clearly doing something right, keeping exciting summer signing Carlos Mendes Gomes confined to the bench.
How to watch
Kick off on Wednesday evening is at 19:45 BST. Good news too, is that the game is available to view on the respective clubs' iFollow pages. The video package is available to buy on a one off subscription for ten pounds.
If unable to watch live, the highlights of this midweek match up will be ready to view on YouTube and club social media platforms.