In what could be a really close match up, Nathan Jones' 12th place Hatters are facing off with the Robins who, just a place above them in 11th, are also coming off a weekend draw. Although a somewhat less dramatic goalless affair with Preston, any points are crucial this early on in the season.
Bristol's draw with Preston extended a club record run without a home league win to 13 games. That said, a win against Cardiff City before that means another win on Wednesday would take Bristol into a run of three unbeaten games in the league.
Coincidentally, both teams have identical records. Six games in to the new EFL Championship season, it's only a goal difference of two that separates Nigel Pearson's men with Wednesday's visitors. Each have two wins, draws and losses to their names respectively.
The home side have no new injury concerns or suspensions to speak of currently. However, after the closely fought draw with Preston, changes if anywhere could come in attack or midfield.
From Saturday's fixture, there were relatively average showings from winger Cameron Pring and experienced EFL striker Chris Martin. Pearson could bring in young Antoine Semenyo and Nakhi Wells - giving both players the opportunity to get off the mark this season.
Midfielder Callum O'Dowda could make a return to action for Bristol. Yet, he still remains in doubt after picking up a knock against Blackpool on the first day of the season.
For Luton, changes may be seen predominantly in the middle of the park. New signing Allan Campbell suffered a nasty ankle ligament injury after a gruesome challenge from Darragh Lenihan on Saturday. Subbed off just inside 11 minutes and subsequently ruled out until at least mid November - it's likely that Henri Lansbury will take the ex-Motherwell man's place.
A brighter point of Saturday's comeback draw was of course Luke Berry's performance. Coming off the bench for his first involvement of the season, Berry's heroics may have earned him a spot in the squad. Amidst new competition in the squad after the recent transfer window, it was a statement performance from the midfielder formally of Cambridge and Barnsley. It will surely have given Nathan Jones something to think about.
Additionally, winger Jordan Clark's availability is still in doubt for the Hatters after the serious concussion he picked up against West Brom back in August. Recovered now from his cracked bone injury after a collision with stopper Sam Johnstone, he only re-joined training in the last week.
Striker Elijah Adebayo missed the Blackburn game due to illness but could make an appearance on Wednesday evening.
Bristol City: Bentley; Vyner, Kalas, Atkinson, Baker, Massengo, James, King, Semenyo, Weimann, Wells.
Luton Town: Sluga; Bree, Burke, Bradley, Naismith, Mpanzu, Lansbury, Berry, Mendes Gomes, Cornick, Jerome.
Ones to watch
Andreas Weimann has become a highly respectable championship striker. Able to play as a forward and even a winger, the 30-year-old who once enjoyed time in the Premier League with Aston Villa has really found his level in the second tier it seems.
Effective at Derby County also, Weimann has really excelled at Ashton Gate presenting the best numbers of his career. Although last season was a mixed bag as he only mustered seven league appearances scoring two goals, this campaign he has hit the ground running.
With four goals in six games. He could be a real threat in this fixture as an in form forward and Bristol's main offensive outlet. His only down side this season has been an inability to score at home, with all his strikes coming on the road. Perhaps Wednesday is the time to change that.
In this section, honourable mentions could go to on-field leaders like Pelly Ruddock Mpanzu or even Cameron Jerome, but in this match its keeper Simon Sluga that could be in for a big day.
Ever since Luton's promotion to the Championship two seasons ago, consistency has always been key. Now, Sluga has had his moments where hearts have been in mouths - fans aghast at a shoddy touch from a back pass for example. But in the big moments, the Croatian international's fine stops have made all the difference.
His three clean sheets in six appearances are also a credit to the defenders. Such is the attitude sometimes that these should be celebrated as much as goals. Picked in direct contrast to Weimann, it'll definitely be interesting to see how this contest plays out.
After a 17-game unbeaten run against Luton between 1992 and 2003, Bristol City have lost six of their seven games against the Hatters.
Luton won this exact fixture last season 3-2, last winning consecutive away league games against Bristol City back in September 1973.
How to watch
This game kicks off at 19:45 BST and will be available to watch on Sky. The match can be found on the Sky Sports Red button and also the compatible Sky Go Extra app.
Additionally, it is accessible through Bristol's streaming service via their website. Tickets are also still available to the fixture but online purchase is advised.