Baggies midfield starlet Alex Mowatt has been absent with a foot problem since the win at home to Birmingham City and is unlikely to return ahead of Tuesday's game, however, Albion manager Valerien Ismael says the injury is being assessed regularly.
Wing-back Darnell Furlong was sent-off in Saturday's loss at Craven Cottage after the denial of a clear goalscoring opportunity and will be suspended for Wednesday's fixture. Youngster Taylor Garner-Hickman could be relied upon in his place.
Tom Huddlestone and Brandon Fleming are expected to be touch and go as to whether they are able to feature in this one.
West Bromwich Albion:
(3-4-3) Johnstone, Ajayi, Bartley, Clarke, Townsend, Livermore, Molumby, Gardner-Hickman, Grant, Robinson, Phillips.
(4-2-3-1) Ingram, Coyle, Bernard, Greaves, Elder, Smallwood, Docherty, Wilks, Moncur, Lewis-Potter, Magennis.
The Baggies head into this one after a mixed run of, picking up two wins and two losses after the resumption of football succeeding the international break.
The defeat will knock the confidence of the Albion players, being the biggest loss so far under the Frenchman's reign.
The Tigers will be optimistic that they can rub salt in the Albion wounds, however their recent form would indicate that there's a slim chance of that happening.
McCann's side have lost their previous four Championship games, scoring in only one of them, with creating and finishing chances becoming a real issue for the second-tier strugglers.
Ones to watch
Jayson Molumby: West Brom
Molumby could come into the side to give an ageing midfield a rest ahead of another tricky clash with Middlesborough.
Keane Lewis-Potter: Hull City
Despite a lack of chances created by McCann's side, the 20-year-old has been at the heart of the little that they have conjured up in front of goal.
With the Albion defence allowing Aleksandar Mitrovic time and space to score on Saturday, they will look to avoid doing the same for Lewis-Potter or there could be similar results.
Where to watch
The match will be televised on Sky Sports Red Button whilst audio coverage will also be available for those in the UK and Ireland via WBATV and Hull City's iFollow, or a live stream of the match on those platforms for those outside of the UK and Ireland.