The Saints are looking to get back to winning ways after their shock defeat at the hands of Hull City before the international break.
Liverpool flying high
Jurgen Klopp's men have enjoyed a fantastic start to the season and have not tasted defeat since they were stunned by Burnley during the second week of fixtures. If Liverpool avoid defeat, it will be three months since their last loss.
Southampton's defence will certainly have to be at their best if they stand any chance of coming away with points. Liverpool's attack have been in frightening form as of late and the attacking trio consisting of Sadio Mane, Philippe Coutinho and Roberto Firmino have been hard to stop in almost all games so far this term.
Southampton haven't been doing too badly themselves. Since Claude Puel arrived from Nice, the Saints have played some lovely football and their new diamond formation seems to be working. Before their back to back defeats against Hull, the South Coast outfit had been unbeaten in ten games in all competitions.
The Frenchman insisted that his side have learnt from their mistakes after the Hull game, meaning tomorrow's clash may not be as cut and dry as many people think.
Both sides come into this fixture with injury concerns of their own. For Liverpool, main men Coutinho and Adam Lallana are both doubts, with the latter expected to definitely miss out. If Coutinho fails to make the starting line up, it will probably mean striker Daniel Sturridge is given another chance to prove his worth to Klopp.
For the home side, the international break took its toll. Midfielders Pierre-Emile Hojbjerg and Dusan Tadic will both be assessed after returning from their national duty. Hojbjerg picked up a knock for Denmark, whilst Tadic suffered a suspected broken nose for Serbia.
England stars Ryan Bertrand and Fraser Forster are also doubtful for the match.
History of the tie
Southampton have only won one of their last six meetings with Liverpool and that was a narrow 3-2 win this March. Before that fixture, 2013 was the last time Southampton tasted victory against the Merseyside outfit.
Southampton have won 28 of the meetings between the two teams, whilst Liverpool have won 51 of the matches.