After playing their first eight matches on the road, Nashville return home to drop the curtain on GEODIS Park against a Union side that sit top of the Eastern Conference.
Midfielder Teal Bunbury will be missing due to a knock on his right knee. Robert Castellanos has a fractured ankle and is out of action for the foreseeable future.
Irakoze Donasiyano is also out as he has an issue with his left thigh.
Sergio Santos is the only player that is questionable to play as the Brazilian forward continues to work his way back from a hamstring injury.
Nashville SC: Willis; Zimmerman, Maher, RomTney; Lovitz, Davis, Godoy, Muyl; Mukhtar, Sapong, Leal
Philadelphia Union: Blake; Wagner, Glesnes, Elliott, Harriel; Martínez; Flach, Gazdag, Bedoya; Uhre, Carranza
Ones to watch
Walker Zimmerman (Nashville SC)
The club captain recently signed a new contract that will keep him in Nashville through 2025, becoming the fourth American and second defender to receive the Designated Player tag.
With 195 appearances in a Nashville shirt, he will continue to be the heart of one of the best defenses in MLS.
Andre Blake (Philadelphia Union)
One of the best goalkeepers in the league is once again in top form, registering four clean sheets for a Philadelphia team that has allowed the fewest goals in the league (five).
The two sides met in last year's Eastern Conference semifinals, won by Philadelphia in a dramatic penalty shootout to reach the conference final for the first time in franchise history.
Hany Mukhtar opened the scoring for Nashville in the 38th minute, racing onto the end of a cross by Eric Miller and nodding past Andre Blake.
The Hungarian thought he had given Philadelphia the lead in the 77th minute, but his goal was disallowed for a foul just before the shot.
Neither team would score for the remainder of the match and in the shootout, Blake saved all four of Nashville's penalty attempts while Jack Elliott and Jack McGlynn scored to send the Union through.
Kickoff is set for 4pm Eastern time.