Inter Miami looks for a third straight victory in MLS play when they host Atlanta United at DRV PNK Stadium.
The Herons topped New England and Seattle with a US Open Cup win over Miami FC.
Atlanta also advanced in the US Open Cup, but has dropped consecutive league matches to Charlotte and Cincinnati without scoring in either match.
Team news
The Herons have a host of players out, including starting goalkeeper Nick Marsman, Robbie Robinson, Ryan Sailor and Victor Ulloa.
Joevin Jones continues to rehab the knee injury he suffered last year while Ian Fray remains sidelined with a cruciate ligament issue.
Edison Azcona, Bryce Duke, Kieran Gibbs and Damion Lowe are all doubtful.
Osvaldo Alonso tore his ACL in the win over DC United and will be out for the foreseeable future.
Machop Choi (leg), Dylan Castenheira (undisclosed), Brad Guzan (undisclosed) and Josef Martinez (knee) have all been ruled out.
Matheus Rossetto is doubtful after tweaking his hamstring, but Emerson Hyndman could feature after recovering from a torn ACL suffered last June.
Predicted lineups
Inter Miami: Callender; McVey, Lowe, Mabika, Yedlin; Gregore; Duke, Taylor, Mota, Lassiter; Campana
Atlanta United: Shuttleworth; Gutman, Robinson, Campbell, Lennon; Sosa, Sejdic; Wiley, Almada, Dwyer
Ones to watch
Leonardo Campana (Inter Miami)
The 21-year old has shined in the number nine position, scoring four goals in his last three matches, including a hat-trick against New England. His 6'2" frame also makes him an aerial threat.
Dom Dwyer (Atlanta United)
With the absence of Martinez, he's gotten more opportunities in attack and he rewarded coach Gonzalo Pineda's faith in him with a braceand an assist in the Red and Black's US Open Cup victory. Look for him to continue to be the key man up front.
Previous meetings
Atlanta recorded a 2-1 victory over Miami in the club's last matchup last October.
The Herons took the lead when video review determined that Guzan caught the foot of Lewis Morgan inside the box with his cleat. Gonzalo Higuain then beat Guzan from the penalty spot.
Miami nearly doubled their lead in the 53rd minute when Higuain latched onto a cross by Kelvin Leerdam, but Guzan made a key save.
Just before the hour mark, Atlanta leveled. Ezequiel Barco drew a free kick and Luiz Araujo drove his shot that appeared to take a slight deflection past Nick Marsman and into goal.
After Martinez had a goal ruled out for offsides, he did net the match-winner after being played in by Araujo and beat Marsman one-on-one.
How to watch
The match will be streamed nationally on ESPN+ and shown nationally on ESPN. Kickoff is set for 1pm Eastern time.