The Boys In Blue were eliminated in the semifinals of the CONCACAF Champions League on Wednesday and haven't played an MLS match in 15 days.
RSL are winless in three after winning three in a row, but have managed draws in their last two contests against Colorado and Toronto.
Anton Tinnerholm continues his rehab from a ruptured Achilles tendon that he suffered last year.
Maxime Chanot is doubtful after picking up an eye injury suffered while on duty with Luxembourg. Maxi Moralez is also doubtful.
RSL has all sorts of injury issues with Zack Farnsworth out indefinitely with an issue with his left ankle.
Nick Besler is still suffering from a nose injury that he sustained during preseason and it is still unknown when he will return.
Bret Halsey is out with an issue to his right ankle.
David Ochoa faces a lengthy spell on the sidelines with a calf injury.
Justen Glad is out with a strained left hamstring.
Aaron Herrera remains out injured following a number of weeks out of training.
Joint top scorer Bobby Wood misses out due to a hamstring problem, while Johan Kappelhof is also absent due to an issue with his left calf.
Jasper Loffelsend is a doubt due to an issue with his hamstring, but the club are hopeful he will be fit enough to feature.
NYCFC: Johnson; Amundsen, Martins, Callens, Acevedo; Morales, Parks; Magno, Moralez, Rodríguez; Castellanos
Real Salt Lake: McMath; Schmitt, Silva, Orozco, Brody; Caldwell, Ruiz; Meram, Kreilach, Chang; Córdova
Ones to watch
Valentin Castellanos (NYCFC)
He could be featured in this segment every match for how prolific he is on the offensive end, but he hasn't scored this season after winning the Golden Boot last year and that's why the Boys In Blue have yet to find their best form.
Damir Kreilach (Real Salt Lake)
The captain scored his 43rd career goal against Toronto last Saturday, leaving him third on the club's all-time scoring list. Part of a five-man midfield, he'll be one that NYCFC will need to keep an eye on.
Real Salt Lake has won four of the five all-time matchups against NYCFC and came away with a 3-1 victory in their last meeting in 2019.
Alex Ring opened the scoring in the fourth minute, received the ball with his back towards goalkeeper Nick Rimando, took a touch and fired into the back of the net.
Jefferson Saverino equalized in the 36th minute and Albert Rusnak gave RSL the lead for good with a finish into the near corner. Besler added a third two minutes from time.
Kickoff is set for 1pm Eastern time.