Anton Tinnerholm remains sidelined as he continues rehabilitation after rupturing his Achilles last year.
Maxi Moralez is also out, still recovering from bruised ribs. Maxime Chanot has an ongoing eye issue and will not participate.
Alfredo Morales picked up two yellow cards against Toronto and he will miss this match through suspension.
Judson is out of action with a knee injury while Benjamin Kikanovic will also be forced to the sidelines with a muscle strain.
Gilbert Fuentes is absent from the team due to personal reasons while Javier Lopez and Marcus Lopez are both doubts due to undisclosed injuries.
Nathan is out through suspension after the league reviewed a dangerous play in the win over Seattle.
Ones to watch
Gabriel Pereira (NYCFC)
The Brazilian scored his first goal for the Boys In Blue last week and assisted on Talles Magno's winner. His continued development into the attack, especially with Moralez out through injury, will be key going forward.
Cristian Espinoza (San Jose Earthquakes)
He became the sixth Argentine to collect a hat-trick in the Earthquakes' victory in Seattle, including the game-winner from the penalty spot in second-half stoppage time. He also assisted on the other goal.
NYCFC: Johnson; Amundsen, Gloster, Callens, Gray; Acevedo, Parks; Magno, Rodriguez, Andrade; Castellanos
San Jose Earthquakes: Marcinkowski; Lopez, Calvo, Nathan, Marie; Remedi; Monteiro, Yueill, Gregus, Espinoza; Ebobisse
NYCFC are unbeaten against San Jose in five all-time meetings, winning four and drawing one. Their last matchup was a 2-1 victory in 2019.
The Boys In Blue scored twice in the final six minutes of the first half. Keaton Parks scored his first career MLS goal and Alexandru Mitrita struck after that to cancel out Chris Wondolowski's opener.
Kickoff is set for 1pm Eastern time.