The third round of the 2022 US Open got underway with action from the top half of the men's draw.
Medvedev, Kyrgios set last 16 showdown
Top-ranked Medvedev had little trouble with Chinese qualifier Yibing Wu, recording his tenth straight victory at Flushing Meadows by a 6-4, 6-2, 6-2 scoreline.
When asked about facing Kyrgios, who owns a 3-1 lifetime record against the Russian, he said "we've played great matches.
"I think all have been quite tight on the scoreboard. It's 3-1 to him, but I will try to do better this time and it will be a great match to watch."
Kyrgios closed out play on Louis Armstrong Stadium with a convincing 6-4, 6-2, 6-3 victory over American J.J. Wolf.
The Aussie saved all seven break points he faced as he attempts to reach the quarterfinals in New York for the first time.
"It was a very tough match for me", he said. "I knew J.J. is a home crowd favorite, I knew I had to be on my guns today and serve well. I'm just really happy to move forward."
Ruud, Carreno Busta among other winners
The 12th-seeded Spaniard next faces 27th seed Karen Khachanov, who moved on when Jack Draper was forced to retire with the score 6-3, 4-6, 6-5 in favor of the Russian.
Finally, 13th seed Matteo Berrettini won the headline match of the day, knocking out 2012 champion Andy Murray 6-4, 6-4, 6-7 (1), 6-3. Alejandro Davidovich Fokina is his next opponent as the Spaniard was a 6-4, 5-7, 6-4, 6-4 winner over qualifier Daniel Galan.