The US Open 2022 began with some style as former winner Andy Murray got off to the perfect start.
The Brit secured his first straight sets win in a Grand Slam for five years as he beat the 24th seed Francisco Cerúndolo 7-5, 6-3, 6-3.
As well as not experiencing any signs of cramping, which the three-time Grand Slam champion has complained about in recent months.
Next up for the former world number one is American wildcard Emilio Nava.
The world number 203 beat Australian John Millman in five gruesome sets, winning 7-6 (9-7), 4-6, 7-6 (7-4), 1-6, 6-1.
Millman who famously took out five-time winner Roger Federer in the 2018 tournament on his way to the quarter-finals.
Murray will now fancy his chances of reaching round three at a Grand Slam for only the second time since his hip-resurfacing surgery at the beginning of 2019.
Last year's winner rolling through in straight sets 6-2, 6-4, 6-0.
France's Arthur Rinderknech will meet Medvedev in round two.
Tsitsipas' world number one hopes dashed
The Colombian qualifier played the match of his life as he triumphed 6-0, 6-1, 3-6, 7-5.
Another shock saw American J.J. Wolf eliminate Spain's Roberto Bautista Agut in straight sets 6-4, 6-4, 6-4.
Former winners out
The Austrian former world number three going down 7-5, 6-1, 5-7, 6-3.
There was one last shock as Indian Wells winner Taylor Fritz bowed out in a surprise loss to fellow American Brandon Holt 6-7 (3-7), 7-6 (7-1), 6-3, 6-4.