Watford come into the game off the back of a superb 3-2 home win against Everton in front of the Sky cameras, which saw summer signing Stefano Okaka grab his first two Watford goals.
Manchester City looking to turn a corner
City started the season off excellently,going undefeated in their first six league games with a big win included in that over their rivals Manchester United.
However, now they have only picked up maximum points twice in their last five games.
Still sitting fourth in the league and three points ahead of the Europa League spots, it would be a major surprise were they to miss out on the top-four - and they'll look to re-assert their title credentials here against Watford.
Watford getting back on form
The Hornets, however, won't be easy pickings. They fought long and hard for a 3-2 victory against Everton which saw them move up to seventh in the league.
They are just six points away from that all-important Europa League spot, and that is a product of their hard work and excellent football thus far.
Last time the teams met
The last time the two teams met was in the New Year as Man city took all three points.
Watford took the lead in the 55th minute with a Ben Watson goal, but it was not enough to see Watford pick up maximum points on the day. Two late goals from Yaya Tourè and Sergio Aguero saw Man City clinch the win.
Watford last beat Manchester City with a 1-0 victory back in 1989 when the second-tier was known as Division Two.
Roberto Pereyra appears likely to return to the squad after serving a one-match ban. Defender Craig Cathcart is expected to be sidelined as he is still struggling with a hernia injury.
Younes Kaboul's involvement is subject a late fitness test after suffering with a calf strain. Valon Behrami could also be out of action with illness. The midfielder was sick on the pitch at half-time in the Everton game.
Man City have just one injury problem. Centre-back Vincent Kompany is out until the New Year with a knee ligament injury. However, their big losses come in the form of star striker Aguero and Fernandinho - who will also be missing this game due to suspensions both picked up in the loss to Chelsea.
Predicted starting XIs
Manchester City predicted line-up: Bravo, Sagna, Stones, Kolarov, Fernando, Zabaleta, Gündogan, Silva, Jesùs Navas, Iheanacho, De Bruyne.
Watford predicted line-up: Gomes, Zuniga, Prödl, Britos, Holebas, Guédioura, Watson, Capoue, Amrabat, Deeney, Okaka.