With the Premier League schedule being jam-packed due to Project Restart, it could well be fair to assume that changes could be in order for both teams for the tie in the East-Midlands. However, considering Brendan Rodgers' team selections in the Carabao Cup this season, it is likely that Jamie Vardy will be selected from the start.
Whilst not having quite rediscovered his shooting boots since the restart, the forward is still the top scorer in the Premier League with 19 strikes. Leicester, who have never won the FA Cup, will hope that he will be able to challenge Chelsea defender Antonio Rudiger.
The German has now established himself as the first-choice centre-back at Stamford Bridge and will have to be wary of Vardy's pace a clinical finishing ability.
What happened last time?
It was certainly an intriguing clash the last time these two squared off. Last competing in early February, the aforementioned Rudiger gave Frank Lampard's men the lead just after half-time with an excellent header, before Harvey Barnes' deflected strike hauled the Foxes level.
Bathed in the late winter sunshine, Leicester then seized the initiative as Youri Tielemans teed up Chelsea-linked Ben Chilwell for a fantastic finish.
Despite having in their hands what would be a crucial three points in context of the UEFA Champions League positions, Rodgers' troops could not hold onto the lead as Rudiger had intervened again with another brilliant header.
There was a chance right at the end for Leicester to win the game but Barnes rolled his effort wide when one-on-one with Willy Caballero.
Neither side have any fresh injuries to report ahead of the game so it will be extremely interesting to see what sides either manager pick as they take a break from Premier League action.
Wideman Christian Pulisic is in tremendous form for Chelsea having netted in wins against Aston Villa and Manchester City recently so will hope to start again. Tammy Abraham also came off the bench against the Sky Blues in mid-week and had a fantastic impact so could well be named in the starting line-up this time around.
Andreas Christensen is also likely to partner Rudiger at the heart of defence, with Fikayo Tomori still recovering from his muscle injury. Callum Hudson-Odoi is edging close to a return though so could be included on the bench.
Elsewhere, Ricardo Pereira and Daniel Amartey remain ruled out for the Foxes, the former proving to be a huge loss. James Justin is likely to continue at right-back as a consequence.
Youri Tielemans, Ayoze Perez, Harvey Barnes and Dennis Praet all started on the bench in the recent 0-0 draw against Brighton & Hove Albion so are somewhat likely to be drafted in against the Londoners.
Leicester City: Schmeichel; Chilwell, Evans, Soyuncu, Justin; Ndidi, Praet, Tielemans; Maddison, Perez, Vardy.
Chelsea: Caballero; Alonso, Rudiger, Christensen, Azpilicueta; Jorginho, Kovacic, Kante; Willian, Pulisic, Abraham.
With Leicester having been beaten finalists on four occasions, more than any other club, and not reached the semi-finals of the FA Cup since the 1981-82 season, Foxes' boss Brendan Rodgers has suggested that his team are driven on by those past failures.
Talking in his pre-match press conference, he said: "The club has not won the competition. So there is a motivation there to do it for everyone. It’s been the aim right from the offset. There’s a big motivation for multiple reasons."
Meanwhile, following their win against Manchester City, Lampard has called on his side to have more belief if they want to challenge for silverware.
The former midfielder said: "There needs to be more belief in this team because what Manchester City showed is, after years working hard together and with a great coach, they are so confident on the ball.
"We have that ability in our team, I believe, but we need to be a bit more confident and believe in ourselves and take the ball and receive the ball."