The Whites sit in 12th place and are playing for the first time in ten days. Last time out they lost 1-0 to Brighton & Hove Albion.
Meanwhile, the Magpies are 16th, winless in their last eight league contests.
The reverse fixture was played at Elland Road on December 16th with Leeds running out 5-2 winners. Jeff Hendrick gave the Magpies a 26-th minute lead with a finish from close range before Patrick Bamford levelled with a header nine minutes later.
Rodrigo converted Jack Harrison's cross to put the Whites on top on 61 minutes only to see Newcastle level through Clark four minutes later. The hosts finished strong as Stuart Dallas, Ezjgan Alioski and Harrison scored within 11 minutes to provide the final margin.
Ones to watch
Callum Wilson has scored just about a third of Newcastle's goals on the season, tallying eight times while also co-leading the Magpies in assists with three. As the lone striker in Steve Bruce's formation, he's relying on the rest of his teammates to provide him with the service necessary to keep up attack.
Patrick Bamford has lit up Premier League defenses in his maiden top-flight season, already finding the back of the ten times in 18 appearances, including netting Leeds' opener in the Whites' 5-2 victory on December 16th.
Leeds manager Marcelo Bielsa has no fresh injury concerns and goalkeeper Illan Meslier is available for selection, as is Diego Llorente after a 45-minute spell for the U-23 side recently.
Kalvin Phillips also featured in that game and should be back in the side following his suspension.
Allan Saint-Maximin came in as a substitute in the loss to Aston Villa and should be back in the starting lineup for this match.
Ciaran Clark, Federico Fernandez and Paul Dummett have all been ruled out while Javier Manquillo faces assessment prior to kickoff.
Newcastle United: Darlow; Manquillo, Clark, Lascelles, Schar, Lewis; Almiron, Shelvey, Hayden, Saint-Maximin; Wilson
Leeds United: Meslier; Alioski, Cooper, Ayling, Dallas; Phillips; Harrison, Klich, Rodrigo, Raphinha; Bamford
Bruce expects another tough test against Leeds and is a big fan of how the Whites play under manager Marcelo Bielsa upon their Premier League return.
"We were two each with 12 minutes to go and I have made two substitutions to try and win the game and opened us up slightly", he said. "We were right in it that night.
"Leeds have been a breath of fresh air so I expect another tough game. I have seen them a couple of years ago and the guy in charge is unbelievable at what he has achieved.
"I haven't been really concentrating on their results, I have had enough to think about myself, but I know them coming to town it is going to be a difficult game."
Bielsa is still wary of the threat Newcastle pose despite their poor run of form, saying "all teams have highs and lows. There's teaams who had bigger injury problems and have had to suffer because of COVID-19 a lot more than others.
"And this has an influence in the succession of the results and their games. In no way do we feel that Newcastle's poor run of form will help us regain ours. It's not a rival's poor run of form that will help us to improve on our own, we have to improve on our own."
How to watch
The match will be braodcast on BT Sport from 18:00 BST with live commentary also available on LUTV.