A win for Barnsley could put them in the play-off places if results go their was whereas a win for QPR will push them even further away from the relegation zone.
Most recently, the R's lost to Birmingham City 2-1 on the weekend, putting an end to QPR's five game unbeaten run.
Charlie Austin opened the scoring, volleying the ball home from close-range.
Kristian Pedersen rose highest to flick a header past Hoops stopper Seny Dieng to level the scoring.
Curling into the corner from 25-yards, Alen Halilovic added a second four minutes later to win the game for the City.
Barnsley beat Millwall at Oakwell to keep their promotion hopes alive.
Club top-scorer Cauley Woodrow finished inside the six-yard area to open the scoring.
Michal Helik scored a second-half volley past Bartosz Bialkowski to win the game for the Tykes 2-1.
Charlie Owens is out for a few more weeks as he carries a knee injury.
Suffering with a cruciate ligament injury, Luke Amos is out until June.
Also suffering with a ACL injury, Ben Williams is out for at least another two months.
Liam Kitching is out as he has a groin injury.
Queens Park Rangers:
Dieng; Dickie, Cameron, Barbet, Kane; Ball, Johansen, Hamalainen; Willock, Bonne, Austin.
Collins; Sollbauer, Helik, Anderson; Brittain, Palmer, Mowatt, Styles; Woodrow, Dike, Morris.
Ones to watch
Queens Park Rangers - Charlie Austin
He’s made nine starts since joining and has scored four goals. He scored on Saturday when the R's lost 2-1 away to Birmingham. His three other goals came in big wins against Luton Town, Watford and Brentford.
Barnsley - Alex Mowatt
The attacking midfielder has been key to Barnsley's excellent season and has scored five goals in the league so far this season and added four assists to his name.
Barnsley 3-0 Queens Park Rangers (27/10/2020)
Where to watch
UK residents will be able to watch the game live on Sky Sports Red on Wednesday, 3rd March with the game kicking off at 19:00 PM.