The Foxes currently sit just one point behind Manchester United in third place, while the Blades are rooted at the bottom of the league in 20th place.
Sheffield United have been struggling for form, losing five of their last six league games and conceding ten goals.
Having won their last fixture 2-1 against Brighton & Hove Albion, Leicester will be heading into their meeting with the Blades full of confidence.
Injuries and suspensions
Leicester continue to be plagued by injuries, with James Maddison, Harvey Barnes, Dennis Praet, Wes Morgan, and Justin James all still out of action.
There could be possible returns for experienced defender Jonny Evans and forward Ayoze Perez after Rodgers commented last week that the pair may be available following injuries.
Wesley Fofana will likely start alongside Çağlar Söyüncü and Daniel Amartey in defence after returning from injury in Leicester's last fixture.
The 20-year-old defender was a massive boost for the Foxes defence in their 2-1 win over Brighton.
The Blades have also experienced several injury woes throughout their difficult season so far. Chris Wilder has been without his usual back-three defence of John Egan, Jack O'Connell, and Chris Basham.
Experienced defender Phil Jagielka is suspended due to picking up a red card last Saturday against Aston Villa. Midfielders Sander Berge and Jack Rodwell are also sidelined due to injury, further adding to Wilder's selection headache.
Defenders Basham and Jayden Bogle could make potential returns to the starting eleven following injury spells.
Will Vardy recapture his scoring form?
Whether he's breaking corner flags or celebrating in front of supporters, Jamie Vardy has been a nightmare for United and their fans.
The Foxes have won all three Premier League meetings against the Blades, with Vardy scoring in two of the fixtures.
Despite his strong record against United, the striker is six games without a goal in all competitions, with his last goal coming from Leicester's 3-1 win over Liverpool.
As Wilder's side have struggled to keep clean sheets due to their defensive issues, this could be the perfect chance for Vardy to get back on the scoresheet and once again trouble the Sheffield back-three.
Can Leicester keep a clean sheet?
Although Leicester goalkeeper Kasper Schmeichel has been in outstanding form, the Foxes have struggled to keep clean sheets.
Rodgers' side have conceded in their last five games in all competitions, as injuries have forced the manager to constantly rotate his starting eleven.
Fortunately for the Foxes, United have struggled in front of goal this season with the Blades netting only 16 goals in their 28 games. Only three other teams have scored fewer goals at this stage of a Premier League campaign in history, (Derby 2007-08, Aston Villa 2014-15, and Huddersfield Town 2018-19).
As the Blades aim to climb up from the bottom of the table, the Foxes will be looking to maintain their spot in the top four.