Bristol City have won three of their five Championship games under new manager, Nigel Pearson, while Blackburn Rovers are looking for their third win in 10 league games, following a poor run of form.
Rovers fell to a narrow defeat at the hands of free-scoring Brentford on Friday evening. Wednesday's hosts have only picked up five points since the turn of February, and Tony Mowbray will be desperate for a win against the Robins, having come under the spotlight recently.
The visitors had notched up seven successive defeats under Dean Holden prior to the arrival of Pearson last month. The former Leicester City manager has since navigated the club to away wins against promotion-hopefuls Swansea City and Middlesbrough, as well as a comfortable 3-0 victory at St. Andrews on the weekend.
Three points for Blackburn could see them temporarily leapfrog Queens Park Rangers, depending on the R's result against Millwall. A win for Bristol City could see them head into the weekend as high as 10th in the Championship.
Both sides go into the game with an extensive injury list. Blackburn will be without Bradley Dack, who suffered another ACL injury on the weekend, and will be out for the remainder of the season.
Lewis Travis also suffered an injury on Friday night, meaning Joe Rothwell and Bradley Johnson could return to Mowbray's starting XI at Ewood Park.
Key figures Lewis Holtby, Adam Armstrong and Daniel Ayala are all ruled out with injuries for Blackburn, making the hosts' job even harder on Wednesday.
For the visitors, Zak Vyner and Adam Nagy will miss out again due to concussion protocols.
Callum O'Dowda could return to the starting lineup, after he scored as a substitute upon his return from injury against Birmingham. However, Andreas Weimann is still unavailable for the visitors, as is Hakeeb Adelakun.
Jay Dasilva is still recovering from a long-term injury sustained in the defeat to Birmingham City before Christmas, while Alfie Mawson has also been out for the last month and is not ready for a return yet.
Finally, Chris Martin is out of the running for the Robins, due to a hamstring injury picked up in training last month.
Blackburn Rovers: Kaminski; Douglas, Harwood-Bellis, Lenihan, Nyambe, Johnson, Rothwell, Trybull, Elliott, Brereton, Dolan.
Bristol City: Bentley; Sessegnon, Kalas, Mariappa, Hunt, Lansbury, Massengo, Palmer, Semenyo, O'Dowda, Diédhiou.
Ones to watch
Harvey Elliott is expected to return to Mowbray's starting lineup against Bristol City. The 17-year-old ranks second for assists in the Championship this term with nine to his name. Having appeared mainly as a substitute in recent weeks, Elliot will be keen to make his mark at Ewood Park given the oppurtunity.
The Liverpool loanee netted in the 3-2 defeat to Watford late last month, taking his tally to five for the season. Elliot has 10 games remaining with Blackburn and is looking to further impress the Reds' hierarchy against the Robins on Wednesday evening.
Bristol City are currently riddled with injuries and could turn to Callum O'Dowda for answers in midweek. The former Oxford United winger recently returned from an injury himself, and scored in a cameo appearance against the Blues in midweek, that ultimately resulted in Aitor Karanka's dismissal.
The Irishman started 13 games for the Robins before his injury in December and was out for nearly three months, prior to his re-introduction on the weekend.
O'Dowda can operate on either wing, and centrally too; Pearson will be delighted to have the midfielder available again and hoping to get the best out of him, with Weimann and Adelakun both ruled out for the foreseeable future.
Just four days after O'Dowda's injury in December, the two sides met at Ashton Gate in a tight affair that finished 1-0 to Bristol City, courtesy of a late Famara Diédhiou tap in.
How to watch
The match is available to watch on NOWTV or iFollow through Blackburn Rovers or Bristol City's respective club websites/apps, with match passes available at £10 for those across the United Kingdom.
Sky Sports customers can also watch live on television, with KO at 19:45 GMT.