Meanwhile, Leicester are aiming to make it three wins in a row having beaten Brighton & Hove Albion and Sheffield United in their last two games.
Here is what United fans should look out for in this fixture.
Jamie Vardy back amongst the goals?
One Leicester player who can never be ruled out as the danger man is Jamie Vardy. Last season's golden boot winner has scored 12 league goals this season but has failed to find the net in his last seven games in all competitions.
The 34-year old's last goal came against Liverpool on 13 February and it goes without saying that he will be hungry for goals.
Although he did not score in the Foxes' 5-0 win against Sheffield United last time out, he may find confidence from his three assists in that game and could be encouraged by the fact that he already has five goals to his name against Man United.
Will Dean Henderson keep his place?
Dean Henderson has impressed when called upon between the sticks for United this season and has been given a run of games in the recent absence of David De Gea.
The Spaniard was given some time off to travel to Spain following the birth of his child and only just returned to warm the bench during Milan on Thursday.
Henderson has generally been the cup competition goalkeeper this season with De Gea occupying the number one spot for league games. However, with De Gea now back within the squad it remains to be seen whether he will regain his place or if Ole Gunnar Solskjaer will keep his faith in Henderson who has kept four clean sheets in the past five games.
After missing ten games through injury, Paul Pogba returned to action with a bang. The Frenchman made an instant impact mid-week as he came off the bench at half-time to replace Marcus Rashford and score the goal that sent United through to the next round of the Europa League.
His impact showed just how much the team has missed him since he went off injured against West Ham United back at the start of February.
The 28-year old has played his way back into the fans' hearts this season and could continue to do so by helping his side to an FA Cup semi-final.