Coincidently, the last time the Reds and the Rossoneri met on the European stage was 11 years ago to this day - in the UEFA Champions League as opposed to this year's Europa League clash.
VAVEL UK rewind to that historic night in Manchester that encapsulated United's dominance on the biggest stage.
United destroy Leonardo's Milan
Sir Alex Ferguson's United came into the last 16 clash with a goal advantage - having won 3-2 in the first leg in Italy.
A rampant United side put four past a Milan outfit that boasted the likes of Clarence Seedorf, Ronaldinho, Thiago Silva and Andrea Pirlo.
That famous night in Manchester saw Wayne Rooney break the deadlock inside 13 minutes with a neatly headed goal inside the six-yard box.
United doubled their lead five minutes later - that main man Rooney scored his 12th goal in nine games with a smart finish to deceive Milan's Christian Abbiati.
Goals from Ji Sung Park and Darren Fletcher in the second half wrapped up a sensational display from Sir Alex Ferguson's side as they advanced into the quarter-finals with a 7-2 aggregate thumping of Milan.
David Beckham returns to Old Trafford
As one United number seven left the year before, another one returned as an opposition player, one the United fans knew all about.
The Red Devils witnessed David Beckham return to the club he had played in 11 trophy-laden years for. Making 263 appearances and scoring 62 times for.
The night was a bittersweet one for the United legend as he was benched by Leonardo until the 68th-minute when the 34-year-old came on in a cameo performance that ended with a standing ovation from the United faithful.