Divock Origi is back in light training after missing five weeks with a knee injury, but this game has come too soon for him to return.
Manager Jurgen Klopp has no other concerns and will be able to choose from the same squad that he had against Arsenal.
The Bees will be without a number of other key personnel as they deal with COVID and injury issues.
Liverpool: Alisson; Robertson, Van Dijk, Matip, Alexander-Arnold; Oxlade-Chamberlain, Fabinho, Henderson; Jones, Firmino, Jota
Brentford: Fernández; Sørensen, Jansson, Pinnock; Canós, Jensen, Nørgaard, Baptiste, Roerslev; Mbeumo, Toney
Ones to watch
Diogo Jota (Liverpool)
With Salah and Mane away from the squad, the Portugese is the main attacking threat for the Reds, having scored 10 goals this season. He is especially finding his form at Anfield, having netted four in his last four at home.
Bryan Mbuemo (Brentford)
Yoann Wissa may also play a part in this match, providing more cover for Brentford and especially Mbuemo.
The first-ever top-flight match between the two sides ended in a 3-3 draw in September.
There is no live coverage of the match in the UK, but Sky Sports will offer highlights on their digital platforms and YouTube channels following the final whistle.
Kick-off is set for 2pm UK time.