The Hatters are hoping to bounce back after a disappointing 3-0 loss to Birmingham City in their last match.
Albion captain Jake Livermore will serve the second game of his suspension following his red card against Sheffield United.
Kyle Bartley will return to the side following his illness, giving a much-needed boost to the Baggies XI.
The vice-captain hasn't played a game under Bruce yet after he was hospitalised with an issue that turned out to be a case of chickenpox.
January signing Daryl Dike has stepped up his recovery from a hamstring injury as he returned to the training pitch on Wednesday.
The American international tweaked his hamstring during his home debut against Peterborough United, but the striker should be available following the upcoming March international break.
Meanwhile, Jordan Clarke and Luke Berry are unlikely to make their return to the first-team squad, with Jones looking to keep injury risks at a minimum to prevent further blows to his side.
(3-5-2) Johnstone, Ajayi, Bartley, O'Shea, Townsend, Mowatt, Molumby, Gardner-Hickman, Furlong, Grant, Carroll
(3-5-2) Shea, Naismith, Lockyer, Burke, Bell, Mpanzu, Lansbury, Campbell, Bree, Adebayo, Cornick
The Hatters come into this one in good form, despite their defeat at the St Andrew's Trillion Trophy Stadium last time out.
They'll be optimistic that they can leapfrog the Baggies, being only a point and a place below them in the EFL Championship.
Bruce's personable character should breed confidence around the Albion training ground, but that's yet to come to fruition on the pitch, particularly in front of goal.
Ones to watch
His hold up play has been exceptional, but the 33-year-old will need support if he's going to prove effective.
Karlan Grant should partner him in a front two to get numbers around him when those lofty balls are played towards him.
Adebayo has proved a handful throughout his first couple of seasons in the second-tier.
In a partnership with Harry Cornick, the 24-year-old could provide a goalscoring touch this Saturday.
How to watch & kick-off time
Audio coverage will be available for those in the UK and Ireland via WBATV and iFollow. There'll also be a stream available for overseas viewers. Kick-off on Saturday February 19 is set for 15:00 GMT.