The Lions will be hoping they can turn their recent form around, with Gary Rowett's side winless so far this calendar year.
His opposite number Valerien Ismael is under growing pressure to reverse their fortunes, the defeat against Preston North End was a game in which fans voiced their frustrations and voted with their feet.
The gloveman was reportedly unhappy with the boss' decision to keep David Button in the lineup ahead of his anticipated return from suspension.
(3-5-2) Bialkowski, Wallace, Cooper, Hutchinson, Malone, Mitchell, Kieftenbeld, Evans, McNamara, Bennett, Afobe
(3-4-3) Button, Clarke, Bartley, Kipre, Townsend, Livermore, Mowatt, Furlong, Grant, Robinson, Diangana
Without a win in 2022, The Lions have a big task to alter their run of poor results in this clash with the Baggies.
However, if there was a perfect time to face up against Ismael's men it would be now.
Last time out at The Hawthorns, Millwall grabbed a point with a physical and battling performance that lead to them coming from behind to pick up a draw.
On-loan Arsenal man Dan Ballard scored to cancel out Kyle Bartley's opener in a resilient performance away from home.
Albion also have their own battle to win after a dreadful showing against the Lilywhites last Wednesday.
Their inability to keep the ball meant they were unable to gain any sort of control over the game and allowed Ryan Lowe's side to take advantage of their wilting confidence.
After going without a win in three away games, they must put on a better showing to convince fans that they're still up to the challenge.
Ones to watch
Albion will be desperate to get themselves back in their fans' good books, and that'll only start if they start firing in the attacking front.
After hitting double figures with a goal versus Peterborough United, he'll be gunning for more strikes in this one.
With top-scorer Bradshaw missing, Rowett needs someone to step up and score the goals.
How to watch