The Whites are unbeaten in their last four matches and are now four points clear of the relegation zone.
Palace are on a run of three losses in all competitions and sit 14th in the table, four points and two places above their visitors.
Nathan Ferguson is sidelined for the Eagles with a hamstring issue after suffering an initial knee injury.
Luka Milivojevic missed out against Newcastle with a thigh injury and may also not feature here.
Adam Forshaw will miss the remainder of the season after suffering a knee injury in training.
Patrick Bamford is still sidelined with a ruptured foot suffered against Wolves.
Tyler Roberts continues his rehab from surgery he had on a ruptured hamstring tendon he suffered in March.
Crystal Palace: Guaita; Mitchell, Guéhi, Andersen, Clyne; Schlupp, Kouyaté, Gallagher; Zaha, Mateta, Ayew
Leeds United: Meslier; Dallas, Cooper, Llorente, Ayling; Klich, Phillips; Harrison, Rodrigo, Raphinha; James
Ones to watch
Conor Gallagher (Crystal Palace)
The midfielder was ineligible to play against parent club Newcastle, but he'll be in the squad here and is a key man to neutralize Leeds' potent midfield.
Rodrigo (Leeds United)
He's been one of the many players revitalized under new manager Jesse Marsch, scoring in three of his last four games. How he plays against Odsunne Edouard in midfield and the ability for his teammates to continue to get him touches will be crucial.
In this fixture last season, Crystal Palace ran riot over Leeds, scoring a convincing 4-1 victory.
Eze then won a free-kick that he took himself and his powerful and precise shot over the Whites' wall doubled the Eagles advantage on 22 minutes.
Patrick Bamford sliced the lead in half five minutes later as he chested down Matuesz Klich's header and fired into the bottom corner.
A bit of good fortune gave restored Palace's two-goal lead as Helder Costa attempted to block Patrick van Aanholt's cross from the left and turned the ball into his own net.
Jordan Ayew made sure the points were in safe when, in the 70th minute, he slotted home from a Wilfred Zaha pass.
The match will be shown live on Sky Sports Premier League. Kick-off is set for 8pm UK time.