Wolves lost for the third time on the bounce, having now gone 324 minutes without a goal. They remain eighth in the table, three points off of a European place.
Story of the match
The Portugese goalkeeper was again called into action, saving more routinely from Mwepu and he then had to push away Welbeck's effort.
Just past the half-hour mark, Romain Saiss handled from Solly March's cross, but Mac Allister's spot kick hit the left-hand post.
A couple of minutes later, Welbeck picked out Trossard and he forced a right-footed save from Sa.
Five minutes before halftime, the Seagulls were in front. Welbeck was tripped by Wily Boly. Sa got his hand to Mac Allister's penalty, but the shot had too much power.
After the interval, Brighton continued to pile on the pressure. Sa saved from Moses Caicedo before Saiss got in a vital intervention to block Mwepu's shot.
Welbeck was next to force a save out of the busy Sa after the hosts gave away possession, his shot held after the Portuguese dove to his left.
On 70 minutes, the visitors doubled their advantage as Welbeck fed Trossard down the right. The Belgian cut inside the challenge of Moutinho before his right-footed shot beat Sa.
Wolves didn't register their first shot on target until the 85th minute, Moutinho seeing his effort blocked by Lewis Dunk with Boly heading straight at Brighton shot-stopper Rob Sanchez.
The points were made safe when the Seagulls broke upfield as Bissouma feathered a low drive past Sa and inside of the left post.
Moutinho hit the post with the last kick of the contest, summing up the hosts' day and keeping Brighton on target for a top-half finish.
Man of the match: Moises Caicedo
Should Bissouma depart the club at the end of the season, the Ecuadorian showed he may be capable of sliding into his role with five tackles and two interceptions.