But at the start of January, their early season hard work has the potential to be undone when two vital members of the squad could be unavailable for a month.
The tournament begins on Thursday 6th January 2022, when the hosts Cameroon face Burkina Faso in Yaounde, with the final taking place just under a month later on the 6th February.
But how exactly will the loss of the two defenders and the AFCON affect Wolves?
The 30-year-old defender has been a member of the Ivory Coast national team since 2020, despite appearing for the French youth teams at under-16, under-17 and under-19 level.
With one goal in nine appearances for the Elephants, Boly played in the final four qualifying games and is likely to be called up to Patrice Beaumelle's squad after starting their two October victories over Malawi.
Ivory Coast fixtures:
12th January 20:00: Equatorial Guinea
16th January 17:00: Sierra Leone
20th January 17:00: Algeria
The Moroccon defender is more experienced at national level compared to his defensive partner Boly, with 50 caps for his nation.
Saiss made his debut for his country in 2012 whilst at Clermont Foot 63 but was not called up again until March 2016. A further spell in and out of the squad, the 31-year-old has been a constant figure since the 2017 AFCON.
Unlike Boly, Saiss has remained fit in the opening 10 games of the season and has completed all but two games under Lage.
10th January 17:00: Ghana
14th January 17:00: Comoros
18th January 20:00: Gabon
How will it affect Wolves?
Depending on when both players will be required to begin their preparations for the tournament, the two defenders could miss some vital games.
Lage has previously discussed the importance of competition inside his squad, and after failed summer moves for Lille's Sven Bottman and Marseille's Duje Caleta-Car, a move in January for another option may be on the club's priority list.
Wolves are not the only team who will be missing key players. If anything, Lage may be one of the managers with the least amount of players out during the competition.
With the AFCON kicking off early in January, here is a list of Wolves' opponents throughout the month and the players they could be without for the fixture:
Watford (H) - 26/12/21
Nicolas N'Koulou (Cameroon)
William Troost-Ekong (Nigeria)
Adam Masina (Morocco)
Imran Louza (Morocco)
Peter Etebo (Nigeria)
Ismaila Sarr (Senegal)
Emmanuel Dennis (Nigeria)
Man Utd (A) - 3/1/22
Eric Bailly & Amad Diallo (Ivory Coast)
Southampton H- 15/1/22
Mohammed Salisa (Ghana)
Moussa Djenepo (Mali)
Brentford (A) - 22/1/22
Julian Jeanvier (Guinea)
Frank Onyeka (Nigeria)
Tarique Fosu (Ghana)
Arsenal (H) - 8/2/22
Thomas Partey (Ghana)
Mohammed Elneny (Egypt)
Nicolas Pepe (Ivory Coast)
Pierre-Emerick Aubameyang (Gabon)