A win or draw for the Boys In Blue guarantees them a home game in the upcoming MLS Playoffs while victory coupled with a loss by Nashville guarantees Ronny Deila's men second place.
Things are much simpler for the Union as a win guarantees them second place while a draw means a loss or draw by Nashville would also give them the second seed.
NYCFC will be without Anton Tinnerholm, who is out with an Achilles injury as well as Nicolas Acevedo and Ismael Tajouri-Shradi, both suffering from lower-body issues. Gudmundur Thorarinsson also has a lower-body injury and is questionable.
NYCFC: Johnson; Amundsen, Chanot, Callens, Gray; Parks, Sands; Medina, Moralez, Thiago Andrade; Castellanos
Philadelphia Union: Blake; Wagner, Elliott, Glesnes, Mbaizo; Fontana, Martínez, Bedoya, Aaronson; Gazdag, Przybylko
Valentin Castellanos (NYCFC)
He's leading the Golden Boot race for top scorer in MLS with 18 goals. In the Boys In Blue's recent three-match winning streak, he's netted five of their 10 goals, further proving that, in a side full of dangerous, attacking players, he's the most important of them all.
Daniel Gazdag (Philadelphia Union)
The Hungarian has settled in brilliantly with the Union, scoring four goals and also contributing five assists. He'll likely play in a more advanced position in this match in support of Kacper Przybylko, which also gives him a chance to showcase his own offensive skills.
This is the third meeting between NYCFC and Philadelphia this year, but the first at Yankee Stadium.
The Boys In Blue won the first match in May 2-0 thanks to goals from Jesus Medina and Castellanos while the Union claimed a 1-0 victory in the second meeting in August on a 67th-minute goal from Alejandro Bedoya.
The match will be streamed live on ESPN +. Coverage in New York will be handled by the YES Network. In Philadelphia, PHL17 has all of the TV coverage while the club's website also has streaming coverage.
Kickoff is set for 3:30pm Eastern time.