The Boys In Blue are in the CONCACAF Champions League semifinals, but were defeated 2-0 by Philadelphia in their last League outing.
Toronto ended a nine-match winless run dating back to last year when they defeated D.C. United 2-1 two weeks ago.
Ayo Akinola is nearing a return, but 17-year old Jakele Marshall-Rutty will undergo a procedure and is out indefinitely.
Jonathan Osorio and Chris Mavinga are back from international duty with manager Bob Bradley facing a decision as to whether to throw them back into action right away.
The Boys In Blue will be without a pair of defenders as Anton Tinnerholm continues his rehabilitation from a ruptured Achilles that he suffered last year while Maxime Chanot is out with an upper body issue.
Toronto FC: Bono; Mavinga-Adebayor, Salcedo, O'Neill; Chung, Osorio, Bradley, Petrasso; Pozuelo, Jimenez, Nelson
NYCFC: Johnson; Amundsen, Martins, Callens, Gray; Morales, Parks; Magno, Moralez, Rodriguez; Castellanos
Ones to watch
Jesus Jimenez (Toronto FC)
Signed from Polish side Gornik Zabrze in the offseason, the Spaniard has two goals and an assist through four matches this season.
His ability to get in behind defenders, drop deep to link up with teammates and ability to be an aerial threat make him the perfect compliment to 2020 MLS MVP Alejandro Pozuelo.
Talles Magno (NYCFC)
While Valentin Castellanos remains the heart of the attack, Magno is the only player on the club with a goal and an assist.
He scored the winning goal that sent the Boys In Blue to the MLS Cup final in Philadelphia last season and will be counted on to provide secondary scoring this season.
NYCFC are unbeaten in their last three matches against Toronto with their last matchup ending in a 2-2 draw.
The lead was doubled when Castellanos pounced on a poor pass by Eriq Zavaleta and he fed Tajouri-Shradi, who finished past Alex Bono.
Pozuelo helped Toronto get back into the game when he slid Richie Laryea in to slot home and six minutes later, Ifunyanchi Achara squared for Pozuelo to level.
ESPN+ will have live streaming coverage with kickoff set for 4pm Eastern time.