The fourth seed lost just 14 points and never faced a break point as he won for the seventh time in the last eight matches in Flushing Meadows, having reached the final last year.
Zverev clinical in straight sets victory
The serve was the dominant shot for both players early in the match with Querrey being pushed to deuce, but coming through the game to take a 3-2 lead.
Zverev, who lost just six points on serve through the first four games, held triple break point after Querrey missed a forehand well wide and he broke after the American sent another forehand wide.
The fourth seed then served for the first set and had three chances to close it out. After netting a forehand on the first, he hammered an ace down the middle to close it out.
Querrey saved a pair of break points in the fifth game of the second set, but couldn't generate any chances on Zverev's serve and he again cracked at a key moment.
With the score 5-5, he faced double break point and double-faulted to hand Zverev a 6-5 lead. Holding two set points, he hammered down another ace for a two-set lead.
The third set was a runaway as Zverev broke twice within the first five games for a 4-1 double break lead. Querrey did well to fight off three match points in a 14-point game, but the German held to love, a crosscourt backhand winner on match point sealing the win.