Their last victory came in an impressive 7-0 away win at Crystal Palace back in December but, since then the Reds have seen a dramatic dip in form.
Liverpool will be desperate to get back to winning ways and will be hoping to come away with all three points.
Jose Mourinho will be seeking to leapfrog Liverpool in the table and claim the fourth Champions League position with a win, as Tottenham Hotspur sit sixth with a game in hand over Jurgen Klopp's men.
Virgil van Dijk and Joe Gomez also remain out of the squad as they step up their rehabilitation.
As for Spurs, they look to have some injury problems of their own as Ben Davies and Matt Doherty look set to miss Thursdays match.
Whilst Dele Alli and Giovani Lo Celso are both still out with injuries.
Tottenham (4-2-3-1): Lloris, Aurier, Alderweireld, Dier, Reguilon, Winks, Dembele, Son, Ndombele, Bergwijn, Kane.
Liverpool (4-3-3): Alisson, Alexander-Arnold, Matip, Fabinho, Robertson, Henderson, Wijnaldum, Thiago, Mane, Firmino, Salah.
Ones to watch
Having scored two goals against Man United and ending Liverpool's four game scoreless run, Mohamed Salah will be eyeing up the opportunity to increase his lead as top goal scorer in the league.
Salah has 13 goals this season one ahead of both Harry Kane and Son Heung-Min with 12.
The Egyptian winger will be flooded with confidence going into the match.
For Spurs, Tanguy Ndombele will be looking to continue his fine form. The midfielder scored an outrageous chip against Sheffield United in their last Premier League match.
He was also substituted on for their FA Cup clash against Championship side Wycombe Wanderers where he bagged two goals including a skilful dribble and finish.
Roberto Firmino saved the day for Liverpool in the reserve fixture. The Brazilian scored a 90th minute header to secure all three points for the Reds. However, Mourinho will be hoping to get his revenge this time around.
Where to watch on TV
The match will be shown live on BT Sport 1 with coverage starting at 7pm and kick-off at 8pm.