Ahead of the clash, Vavel take a look at three memorable games that took place between the two sides at Molineux.
Wolves 3-0 Southampton- 10th April 2009
Towards the end of a campaign that saw the Wanderers win the Championship title, a lightning start helped guide Wolves to a comfortable 3-0 victory.
Five minutes later Jody Craddock doubled the hosts lead when he converted past Kelvin Davis after latching on to another Jones cross.
The rout was then completed on the 19th-minute mark when Jones netted from the penalty spot after David Edwards was penalised inside the area.
For the remainder of the game Vokes, Andy Keogh and substitute Marlon Harewood were all close to adding a fourth, but the three points were already wrapped up as Wolves went five points clear at the top of the table.
Wolves 2-0 Southampton- 29th September 2018
A late showing by the Wanderers saw Wolves claim three points against the Saints towards the start of their first season back in the Premier League.
In a game of few clear cut chances, the attacking threat of substitute Adama Traore ultimately proved to be the difference.
This result at the time after seven games moved Wolves up to eighth place in the Premier League table.
Wolves 2-2 Southampton- 4th March 2008
A last gasp Jason Eusell strike rescued a point for the Saints on the road to Wolves.
Sylvain Ebanks-Blake broke the deadlock with a powerful hit before Gregory Vignal levelled up the scores from the penalty spot.
Vignal was dismissed for a second bookable offence before Ebanks- Blake volleyed home two minutes from time.
Then when the points seemed to be heading to Wolves, Eusell's late header stole all three points off Wolves.