It was a contrasting performance from the Foxes who after looking like the better side in the first, struggled to find their rhythm after the break and failed to conjure any significant chances against the Červenobílí to find an all-important away goal.
The return fixture is now evenly poised ahead of the second leg at the King Power Stadium next Thursday, with both teams likely to fancy their chances to progress to the last 16.
Foxes wasteful with chances
Despite an overall lacklustre look about Leicester's play, there were still arguably enough chances for Brendan Rodgers' side to come away from the Czech Republic with a win.
Harvey Barnes, who has improved drastically on his finishing this season, had the most chances, missing three good opportunities to put the Foxes in front.
Two of his efforts were saved by Prague keeper Ondřej Kolář however his third chance saw the 23-year-old free at the back post from a corner, only to rush and squander his shot well wide of the goal.
Barnes will be disappointed not to have got on the scoresheet when he looks back at this game and as Leicester's second-highest goalscorer with 12 goals, knows he should have added to his tally at the Sinobo Stadium.
Luke Thomas is a star in the making
In terms of performances, there weren't many stand-out individual displays, however one player that caught the eye for Leicester was Luke Thomas.
The 19-year-old was brought into the side as the only change from the win against Liverpool, replacing Ricardo Pereira who was left at home as part of his phased return to action following his long-term injury.
Playing in the left wing-back role, the academy graduate linked up well with Barnes, bombing on from a deeper position to overlap the winger and join the attacking line whilst also performing his defensive duties to a high standard, dealing with danger man Abdallah Sima confidently.
Thursday was Thomas' 11th appearance of the season so far and with each game seems to get better and better. It wouldn't be a surprise to see him retain his place for Sunday's trip to Aston Villa, but one thing for certain is that the Foxes have yet another talented youngster on their books.
Advantage Leicester in the second leg?
Although the performance won't have particularly satisfied Brendan Rodgers, in terms of results, it's hard to look past the Northern Irishman being the happier of the two managers at the full-time whistle.
An away goal would have been a major boost but they will return to Leicester knowing that Slavia Prague will have to come out the blocks and attack to find an away goal themselves.
It's this style of football from the opposition that suits the Foxes best and although they don't have a marginal advantage heading into next week, they will feel confident they can get the job done.