The Foxes suffered a humiliating exit in the UEFA Europa League last time out so will be keen to get back to winning ways. Meanwhile, the Gunners were also in European action as they overcame Benfica to book their place in the last-16 of the competition.
Here is how we expect both sides to line up in the East-Midlands:
There should be a familiar look to the Leicester defence considering all of the injuries that the Foxes are currently suffering. Wesley Fofana, James Justin and Wes Morgan all remain ruled out, meaning Caglar Soyuncu and Jonny Evans are more than likely going to be the centre-back pairing.
The only contentious issue is at full-back. Ricardo Pereira and Timothy Castagne should return to the starting lineup having started on the bench in the defeat against Slavia Prague. However, Pereira played extremely well further forwards in the Premier League victory against Aston Villa so could be pushed up the pitch again, opening up a space for Luke Thomas.
Wilfred Ndidi and Youri Tielemans have been impressive in a double-pivot in midfield so far this season so are sure to start. James Maddison is ruled out, with Ayoze Perez and Dennis Praet also on the sidelines. This leaves Kelechi Iheanacho as realistically the only option to take up that position and he is eligible to play once again following his suspension in the Europa League.
Another returnee will also be Harvey Barnes, who started on the bench in the Europa League. He will likely support striker Jamie Vardy, who whilst in a difficult run of form, has scored 11 goals in 12 games against Arsenal.
Starting XI: Schmeichel; Castagne, Soyuncu, Evans, Thomas; Ndidi, Tielemans, Iheanacho; Barnes, Pereira; Vardy.
The Gunners do not have all too many injury worries ahead of the trip to the King Power Stadium. Only centre-back Rob Holding is a doubt due to concussion protocols. A defensive pairing of Gabriel and David Luiz are expected, then. First-choice full-backs Kieran Tierney and Hector Bellerin are more than likely to start too.
Mohamed Elneny appears to have forced himself firmly back into first-team reckoning and should continue his midfield pairing with Granit Xhaka.
Bukayo Saka, Martin Odegaard and Pierre-Emerick Aubameyang all performed well against Benfica so are all contenders to start, whilst Emile Smith-Rowe’s positive form since New Year could also see him included from the off.
Starting XI: Leno; Tierney, Luiz, Gabriel, Bellerin; Xhaka, Elneny; Saka, Smith-Rowe, Odegaard, Aubameyang.
Despite some distance between the two in the Premier League table, this game feels extremely important considering Leicester’s UEFA Champions League ambitions. They were severely underwhelming against Slavia and with a long list of injuries, they might well struggle against a Gunners’ side coming into this game on the back of a win.
Leicester have done well against Arsenal on recent seasons however, so they will be hoping to continue that good run.
A draw could be the most likely result between the two.
Leicester City 2-2 Arsenal