Coming off the back of a disappointing draw at home to AC Milan in the Europa League, Manchester United host West Ham United with further injuries added to an already depleted squad.
Ole Gunnar Solskjaer will have a number of decisions to make when selecting his squad, particularly in attack given the lack of options at his disposal.
With Edinson Cavani and Marcus Rashford already sidelined with injury, in their absence, the United boss opted for a front three of Mason Greenwood, Anthony Martial and Daniel James on Thursday.
However, Martial was forced to withdraw at half-time with a hip injury, rubbing salt into the already gaping wound that is the injury list.
Cavani has already been ruled out of Sunday's game while Martial and Rashford are unlikely to feature thus leaving Solskajer with a selection headache when it comes to the attackers.
These injuries now leave Greenwood as the only fit natural striker in the side meaning the 19-year old will most likely be leading the against the Hammers.
A starting place in his natural position as a striker could give him the confidence he needs to get back amongst the goals and recreate the scintillating form he produced last campaign.
Although the injury to Martial has dealt his manager a blow, there was a positive to come out of his withdrawal. 18-year old January arrival Amad Diallo came into the game to score his first goal for the club.
The clever header with his back to goal was certainly the highlight in a performance that also included stats such as 100% of tackles won, 84% pass accuracy and four ball recoveries.
Having already blown opponents away in his handful of games for the Under 23s, Diallo is now beginning to stake a claim for a more regular place in first-team and Thursday's showing may have come just at the right time for the young forward and his manager.
With the notable absentees in the squad, now would be the perfect time to integrate the Ivorian into the team with a start.
So, with Greenwood and Diallo occupying two of the front three positions, that leaves the other free for the in-form James.
The Wales international has really stepped up as of late and is starting to replicate his early form in the red shirt with goals against Southampton, Real Sociedad and Southampton recently.
If these three are given the nod against West Ham, it could be the ideal opportunity for them to prove to their manager that they are worthy of a more regular starting place.