Nuno Espirito Santo's side have not been in action since a 1-0 defeat to Liverpool three weeks ago, while the Hammers have not played since a 3-3 draw with Arsenal on March 21.
Ahead of the game, VAVEL take a look back at three Wolves wins over West Ham at Molineux in years gone by.
Wolves 4-2 West Ham, 15 January 2005
Wolves put a dent in West Ham's promotion hopes as they beat Alan Pardew's side 4-2 in January 2005.
Kenny Miller put Wolves ahead just before the half-hour mark by lobbing the ball over Jimmy Walker's head from close-range, but Bobby Zamora equalised for the Hammers just seven minutes later.
Miller put Wolves back in front early in the second half with a far-post volley that Walker should have easily stopped, before Zamora drew West Ham level for a second time by tapping in Marlon Harewood's low cross.
Captain Paul Ince sent a near-capacity Molineux into raptures with a third goal for Glenn Hoddle's side to give Wanderers the lead yet again, while Carl Cort made the points secure as he scored the fourth on 75 minutes.
Wolves would not lose another league game in the 2004-05 season, but 10 draws from their last 18 games cost them the chance of a real promotion push as they finished 9th. West Ham, meanwhile, finished 6th, and were promoted at the Millenium Stadium as they beat Preston North End 1-0 in the play-off final.
Wolves 3-0 West Ham, 29 January 2019
Wanderers would have to wait 14 years for their next win over West Ham at Molineux, which came in a comfortable 3-0 Premier League victory in 2019.
After a goalless first-half in which the hosts were denied two seemingly clear penalty claims, Romain Saiss broke the deadlock by heading home Joao Moutinho's corner to finally beat the seemingly invincible Lukasz Fabianski.
Another Moutinho set-piece made it two as his free-kick was brilliantly flicked home at the near post by Raul Jimenez, before the Mexican picked up his eighth Premier League goal as he chipped the ball over Fabianski after being put through by Diogo Jota.
The two wins Wolves picked up against the Hammers would prove to be crucial at the end of the season, as they beat Manuel Pellegrini's side to a Europa League place by five points.
Wolves 2-0 West Ham, 4 December 2019
West Ham's last trip to Molineux ended in defeat as Wolves extended their unbeaten league record to 10 games following a 2-0 win in December 2019.
Another Joao Moutinho corner caused Pellegrini's side trouble as it was fired home at the near post by Leander Dendoncker, who picked up his first goal of the campaign.
Unlike on their last visit to WV1 the Hammers did trouble Rui Patricio as Pablo Fornals and Robert Snodgrass probably should have scored, but Patrick Cutrone's late strike sealed the points for Nuno's men who rose to fifth in the Premier League table.
Wolves would finish seventh when the season was finally able to be completed in July, while the late-December appointment of David Moyes was able to help West Ham stave off relegation by five points.