The sides come into match-day one off of the back of a busy pre-season. Shrewsbury went unbeaten winning all of their games, meanwhile Burton had an inconsistent warm-up period.
It'll be the first time that The Shrews have had fans at a league match in over 500 days. It's set to be a special occasion for Steve Cotterill's side.
Luck could be on the visitors' side, Salop have only won two out of their last ten opening fixtures. Despite being at home for 15 of their last 19 opening day games too.
On the other hand, Albion have only beaten their opponents away from home once in the Football League, this came back in 2015 during Jimmy Floyd-Hasselbainks first spell at the club.
There's been an overhaul at Town this summer with Cotterill bringing in multiple new names, including former Everton centre half Matthew Pennington - who could be in line for his first competitive game for the club since signing permanently. He was on loan at New Meadow last season.
Shrewsbury don't really have injury problems other than Ethan Ebanks-Landell who could face a late fitness test as he has been nursing a hip problem throughout pre-season. The 28-year-old could still start though.
As for the visitors, Hasselbaink will be without two strikers, firstly Louis Moult who signed this summer - the 29-year-old has been ruled out for up to five months after sustaining a nasty injury against Leicester City a couple of games back.
Both had promising pre-seasons. Hemmings should be back for match-day two. Meanwhile new signing Moult won't feature until at least Christmas.
Shrewsbury Town: Marosi; Pennington, Leahy, Nurse; Bennett, Davis, Vela, Ogbeta, Whalley; Udoh, Bowman. (3-5-2)
Burton Albion: Garratt; Brayford, Leak, Mancienne, Hamer; O'connor, Shaughnessy; Powell, Maddox, Smith; Akins. (4-2-3-1)
Ones to watch
Ryan Bowmanis all that Salop have needed in recent times. The kind of attacker they've been crying out for. After scoring his fair share of goals at previous club Exeter City, he should give Cotterill something to be positive bout in attacking areas.
Bowman is quite the allrounder, he has speed, strength and height. He'll certainly cause teams trouble this season. Dropping deep is a trait of his, creating space and movement for his team mates - he should have a hand in a respectable amount of goals and assists this season.
Omari Patrick - Burton Albion
Omari Patrick signed for the Brewers this summer, he comes with quite the reputation.
The former Bradford City man has enjoyed a recent campaign up in Cumbria with Carlisle United. He only scored seven goals, across a number of attacking positions. His versatility has to be one of his strongest traits, and the Staffordshire side may benefit well from this.
If Patrick is on the pitch, balls in behind defences could turn out to be a good tactic for Burton. The 25-year-old has lightening speed and good finishing ability, which work hand in hand together in this division.
Shrewsbury are unbeaten in four games against the Brewers. Last season, they drew 1-1 at home, and then won 2-1 at The Pirelli Stadium.
How to watch
For those who are fortunate enough to attend the game at New Meadow, it will be kicking off at 15:00 BST. However, if fans don't have a ticket, there won't be anywhere official to watch the game. Fans can listen to audio via local radios, or an iFollow pass can be purchased from club websites, where those outside of the UK can watch a stream of the game.