A win for Jimmy Floyd Hasselbaink's men could see them top the table whilst Mark Bonner will be hoping his side can avoid being dragged into a relegation scrap early on.
Cambridge's biggest blow is losing their captain, Greg Taylor. The skipper, who was subbed off after half an hour against Plymouth Argyle isn't expected to return against Burton, Bonner told club media: "Until we get the final real details, we do not want to speculate and go into too many details on time scales and type of injury – but we do know it will be a long-term injury."
Jubril Okdeina is also still out but is making progress with the physio's and is expected to be back training on grass in a couple of weeks. Jack Lankester is back with the squad but not expected to feature against Burton and the same can be said for Leon Davies.
As for the Brewers, well they are still light in attack with Kane Hemmings, Louis Moult and Jacob Maddox. However, despite this there are no fresh injuries to report.
This means it is likely that Omari Patrick will lead the line once again as he looks for his first goal in his new position.
Cambridge United: Mitov, Williams, Jones, Dunk, Iredale, Tracey, Digby, May, O'Neil, Brophy, Ironside
Burton Albion: Garratt, Brayford, Shaughnessy, leak, Hamer, Mancienne, O'Connor, Smith, Powell, Akins, Patrick
Ones to watch
Striker Joe Ironside has scored three goals in three games in the league so far this season despite the clubs below average run. His penalty secured the club in their latest tie against Plymouth and he also bagged the equaliser in the clubs first game against Oxford United from the spot.
A Sheffield United academy graduate, Ironside has made 158 career appearances scoring 32 and assisting 14. The 27-year old has only played against the Brewers once in a game he won with Cambridge United in the EFL Cup. However, he didn't score and now with from on his side he'll be looking to get that goal.
Jonny Smith could once again take this for Burton but considering he had it in the last preview, it would be right to give it to the keeper Ben Garratt. He put in a man of the match performance against Sunderland could be the difference again.
A clean sheet against Sunderland is good enough to boast about but add to that seven saves, two inside the box, 19 accurate passes and 14 accurate long balls. So far this season he has only conceded one goal, keeping two clean sheets in the league. In his all career he has kept 65 clean sheets in 283 games.
Garratt has been with Burton since the 2019/20 season but had only made five appearances up until last season where he made 28 league appearances.
The two sides have only met three times since 2010 with Cambridge just tipping the edge, winning two compared to Burton's one.
It's been a high scoring game whoever has won with 15 goals in three games. The last game saw six goals with Cambridge winning 4-2 away at the Pirelli Stadium.
How to watch
The game will be available to watch on the streaming platform IFollow. For all fans outside the UK it will also be available via IFollow.