The Seagulls had previously been in fine form and had enjoyed a seven-match unbeaten run in the division - their longest to date.
Burnley, in contrast, have only won one game all season, but will be confident of getting a result having never lost at the AMEX Stadium across four meetings.
Despite previously losing at Old Trafford, Brighton's recent efforts have been nothing short of spectacular and a win could see a rise to eighth.
Brighton have no new injury concerns after the 2-0 loss to Man United, although Enock Mwpeu and Jemery Sarimento will remain sidelined with respective injuries.
Duffy's inclusion could also warrant a return to the starting line-up for Tariq Lamptey, with the full back gunning for consistency after a lengthy injury.
Burnley's talismanic January signing Wout Weghorst was forced off against Liverpool in the second half, and may be unavailable at the AMEX.
In his potential absence, Jay Rodriguez and Ashley Barnes will be vying for a starting spot at the front of the XI.
Brighton: Sanchez; Lamptey, Duffy, Webster, Cucurella; Bissouma, Gross, Mac Allister, Moder; Trossard, Maupay.
Burnley: Pope; Roberts, Tarkowski, Mee, Pieters; Lennon, Westwood, Brownhill, Cornet; Barnes, Rodriguez.
Ones to watch
Duffy endured a torrid loan spell at Scottish outfit Celtic last season, and looked set for a spluttering end to his career.
The veteran defender served as a key figure as Brighton's laudable season commenced, and despite injuries and rotation affecting play time of late, Duffy can still be pleased with his efforts.
His aerial presence and leadership could be vital against a Burnley side that will look to utilise wing play and implement their physical presence against the Brighton backline.
How to watch
The fixture is not available to watch on UK television, although coverage can be followed via BBC's Final Score or Sky Sport's Soccer Saturday.