Neither side boasts a particular good record in the competition in recent years but current league form favours the Yorkshire outfit.
The Terriers currently sit in the Championship play off places and are unbeaten in the league since the middle of November with their hosts struggling as of late, but the cup could provide a distraction for Burnley considering their poor league form of late.
Burnley boast a number of selection issues ahead of the FA Cup tie with them only having 16 senior players fit and one major issue being in the dugout.
Sean Dyche will miss the game after a positive Covid-19 test along with a number of backroom staff which means assistant Ian Woan will take The Clarets on Saturday afternoon.
Woan confirmed that Johann Berg Gudmundsson is 50/50 to whether he will be available to take on Huddersfield.
Connor Roberts is back in training after his illness but won't be ready for the cup game.
As for the visitors, winger Aaron Rowe will miss the game after a positive Covid-19 test.
Ones to Watch
Burnley - Matej Vydra: This'll be the time for Matej Vydra to make his mark and cement a place in the Burnley side. The Czech International hasn't featured much this season but with the absence of Cornet for at least a month, it's time for Vydra to step up and be the goalscorer Burnley are desperate for.
Huddersfield - Lewis O'Brien: Potentially a scouting mission for Burnley's recruitment team because O'Brien is a talented midfielder. The 23 year old has been linked with Burnley in the past and his ability to dictate the play in the midfield could be the edge for Huddersfield on the road at Premier League opposition and attract a lot more interest.
Burnley: Pope, Bardsley, Collins, Long, Pieters, Lennon, Stephens, Brownhill, Gomez-Mancini, Rodriguez, Vydra (4-4-2)
Huddersfield: Schofield, Perason, Lees, Colwill, Thomas, High, O'Brien, Toffolo, Koroma, Sinani, Ward (3-4-2-1)
Although these sides are both in different leagues, the form of both sides couldn't be more contrasting. Huddersfield are one of the form teams in the Championship which has seen Carlos Corberan's team break into the play off places in the few weeks.
As for Burnley, they are probably one of teams in the worst form in the Premier League. There is no escape from the fact that The Clarets have only won once in the league this season and the only cup victories coming in the Carabao Cup wins over Newcastle and Rochdale.
This could provide an important distraction for Dyche, Woan and co. to really help bring players into form and change their fortunes in the process.
Burnley will be up for this but Huddersfield will also fancy their chances. It could be tight and with no replay this one could see extra time and potentially penalties.
Prediction - Burnley 2-1 Huddersfield (AET)
How to Watch
The game is not being broadcasted in The UK but has been selected for international TV so kick off is 12:30 BST with highlights available on the BBC at around 10:30pm.