Carlisle's excellent run of form recently sees them in a much better position than they were this time last month when they sat in 22nd place, just two points clear of the drop zone.
Now they sit 18th, a healthy, but by no means comfortable, six points clear of the dreaded drop to the National League.
Northampton currently sit second in the division and have closed the gap to runaway leaders Forest Green Rovers to eight points but will be wary of teams around them who have games in hand.
Carlisle boss Paul Simpson has a few injury concerns ahead of Saturday's game.
Both Rod McDonald and Brennan Dickenson are back in training and could make the bench for the Cumbrians at the weekend.
Both Gime Toure and Kelvin Mellor are making progress with their recoveries but are unlikely to feature.
Northampton boss Jon Brady has no fresh injury concerns ahead of the game.
Carlisle United: Howard, Riley, Simeu, Feeney, Mellish, Armer, Gibson, Guy, Devitt, Patrick, Dennis.
Northampton Town: Roberts, McGowan, Horsfall, Magloire, Guthrie, Sowerby, McWilliams, Lewis, Hoskins, Appere, Pinnock.
Ones to watch
Omari Patrick has been Carlisle's man of the moment in recent weeks and his goals have been crucial in pushing United away from the relegation zone.
Patrick has been in incredible form and has scored three in his last three, doubling his goal tally for the season to six goals in 12 appearances.
The 25-year-old scored to begin United's comeback against Oldham Athletic last weekend before Morgan Feeney's last-minute winner earned the Blues a huge win in their fight for survival.
It may come as a shock that Northampton's one to watch is a central defender, however, Fraser Horsfall has been fantastic in front of goal from this season.
Along with Sam Hoskins, Horsfall is the Cobblers' top scorer this season with eight goals.
The Yorkshireman has been so dangerous from set-pieces for Jon Brady's side this season and scored twice last weekend in Northampton's 3-2 win over promotion rivals Tranmere Rovers.
The two sides have met 44 times since their first meeting in September 1958.
Northampton have the slight upper hand with 18 wins, 14 draws and 12 Carlisle wins.
Northampton also have a strong record at Brunton Park and haven't lost there since 2014.
The last time the sides met was in the reverse fixture back in October when the Cobblers were 3-0 winners.
Where to watch on TV
While the game is not available to watch live in the UK and Ireland, overseas supporters can watch the game via either clubs' iFollow service.
Supporters in the UK can use iFollow to listen to the match live.