Both sides are sat in the automatic promotion places of League Two after 34 games with Northampton in second on 57 points and Tranmere third on 56.
The Cobblers will be celebrating their 125th birthday and will be wearing a special kit to mark the occasion.
Northampton will be without Chanka Zimba and Idris Kanu who are both recovering from long term injuries.
Midfielder Jack Sowerby has been sidelined in recent weeks for the Cobblers but Town boss Jon Brady has confirmed Sowerby is close to a return.
Tranmere have no new injury concerns and are expected to be without Paul Glatzel who is nearing a return from injury.
Jay Spearing is a doubt but has returned to the training field in the past week as he recovers from a knee injury.
Northampton Town: Roberts, McGowan, Guthrie, Magloire, Horsfall, Koiki, McWilliams, Lewis, Pinnock, Hoskins, Appere.
Tranmere Rovers: Doohan, Dacres-Cogley, Davies, Clarke, MacDonald, Hawkes, O’Connor, Warrington, Morris, Hemmings, Nevitt.
Ones to watch
Mitch Pinnock has been at the centre of everything good Northampton have done going forward this season, particularly from set-pieces.
The winger has been labelled 'Postman Pinnock' by the club this season and it's no surprise considering he is second in the assist charts in the fourth tier this season with 11 assists behind only Forest Green Rovers' Kane Wilson who has 12.
The 27-year-old has also been good at scoring goals as well as assisting them and most recently netted on Tuesday night in the Cobblers’ 1-1 draw with Walsall and now has five goals in the campaign.
As for Tranmere, Kieron Morris has been their biggest threat going forward this season.
Goals in the Rovers squad have been distributed all over the place and Morris has the most with five so far this season.
Morris has also shown plenty of creativity with four assists this season and will be keen to pick up a few more at Sixfields on Saturday.
The two sides have met 43 times previously and their record is pretty even with 16 Northampton wins, 12 draws and 15 Tranmere wins.
Last time the sides met was on Merseyside in the reverse fixture back in October where Northampton were 2-0 winners.
The Cobblers can also take confidence from the fact that they haven't lost to Rovers since December 2014.
Where to watch on TV
While the game is not available to watch live in the UK, overseas supporters can watch the game via either clubs' iFollow service.
Supporters in the UK can use iFollow to listen to the match live.