The Italians are looking in good shape heading into this Summer's Euro's in France where they will come up against Belgium, Republic of Ireland and Sweden in what is looking a tough Group A. A victory in this match isn't essential but, if they could get a boost by beating one of Europe's best sides, it can only be a good thing for their confidence following their dismal showing at the 2014 World Cup which saw them crash out at the group stages following losses to Uruguay and Costa Rica.
Italy under Antonio Conte are generally a side who are difficult to play against and are well set-up defensively with the Juventus centre-halves a big part of their defensive gameplan.
As for the Spanish, they have an abundance of high quality players to call upon and each time a squad is announced, there are some unlucky players who miss out.
Just like the Italian's, Spain endured their struggles at the World Cup in Brazil and were also eliminated at the group stages which came as a huge disappointment for the nation as a whole. On their day Spain can beat anyone but, over the past few years they have found it tough to find levels of consistency, but have of late improved to lift themselves back up to number three in the world rankings coming into these matches.
The last time that these two sides met was in March 2014 when Spain narrowly came out on top in Madrid winning 1-0.
The game was a close one, which is something that regularly happens when these two meet, and was played out in front of a crowd of 35,000, marking both sides preparation for the 2014 World Cup.
Spain have gained an edge over Italy in recent times, having won four of the pairs last six meetings with one draw and the solitary win for the Azzuri.
This is Italy's first match since the turn of the year so they have little form to talk of, yet in their previous six fixtures they have gained four victories, as well as a draw and a defeat.
Their most recent fixtures came in the November-break when they faced Romania and Belgium. Against the Belgians they lost 3-1 despite taking a third-minute lead through Antonio Candreva, whilst they drew 2-2 against fellow-Euro 2016 qualifiers Romania thanks to goals from Claudio Marchisio and Manolo Gabbiadini.
As for Spain, they are on a run of seven-straight victories, with their last defeat coming in March of 2015 at the hands of the Dutch. Since then, they have reeled off qualifying wins over Belarus, Slovakia, Macedonia, Luxembourg and the Ukraine.
In their most recent friendly, they overcame England 2-0 in Alicante thanks to goals from Mario Gaspar and Santi Cazorla. You could argue that the opposition has not been the most challenging for Spain of recent times, but they are getting positive results, which they hope will continue against Italy, before they face Romania on Sunday, March 27th in Cluj.