The reverse fixture at Stamford Bridge earlier in the season saw the visitors come from 2-0 down to draw 2-2.
Chelsea Vavel has taken a look at three players to have played for both teams.
Centre back Cahill began his career at Aston Villa and spent four years at the club.
During the 2007/08 season, he went on loan to the Blades where he featured 16 times and scored two goals.
He then moved to Bolton Wanderers in 2008 and spent four years at the Trotters before joining Chelsea in 2012.
Whilst at the Blues, Cahill won every major trophy possible, including the Champions League just four months after joining the club.
At the start of this season, he joined his current side Crystal Palace on a permanent deal.
Harley spent his youth career at Chelsea and made his professional debut in 1998.
He was part of the Blues’ FA Cup winning side in the 1999/00 season, and made 42 appearances for the club in total.
The left back joined Sheffield on a permanent deal in 2004 after having two loan spells there whilst at Fulham.
He made 48 appearances for the Blades before joining Burnley in 2005.
After retiring from football at Maidstone United, he is now a Development Squad Assistant at Chelsea.
Like Harley, Shipperley started his career at Chelsea and featured 40 times for the club.
His first game in a Chelsea shirt came in the Premier League’s first season in which he made a substitute appearance against Southampton.
He also had a loan spell at Watford in 1994 before joining Southampton in 1995.
In 2005, the striker joined Sheffield on a free transfer, where he scored 11 goals in 39 games and helped them gain promotion to the Premier League.
Shipperley announced his retirement from football in 2007.