Despite the prospect of facing Pep Guardiola's side in the next round, both sides are expected to rotate and make multiple changes.
New signing Conor Hourihane could be handed his debut after signing on loan from Aston Villa.
Swansea will be without George Byers and Ryan Bennett as the pair remained sidelined through injury.
Yuri Ribeiro is suspended after his red card in the midweek 2-1 defeat to Middlesbrough.
Academy graduate Ryan Yates will sit out of the trip to Wales after picking up a calf injury against Boro.
He will join Harry Arter, Jack Colback and Luke Freeman on the sidelines as the trio are still struggling with injuries.
Woodman; Naughton, Cabango, Guehi, Garrick, Hourihane, Dhanda, Grimes, Manning, Gyokeres, Routledge.
Nottingham Forest (4-2-3-1):
Smith, Jenkinson, Worrall, Mbe Soh, Bong, Bachirou, Sow, Lolley, Mighten, Guerrero, Taylor.
Ones to watch
Conor Hourihane - Swansea City
The 29-year-old midfielder was a hit in the Championship for Aston Villa in their promotion-winning season. The Irishman scored seven times from central midfield and played a key part for Dean Smth's side. He could potentially make his debut on Saturday and could be the key to victory. His wand of a left foot can create chances for his new teammates or even trouble the Forest goal with his ability to find the net from long range.
Lyle Taylor - Nottingham Forest
After joining on a free from Charlton Athletic in the summer, the striker has had a decent start to life in Nottingham. The 30-year-old has scored four goals in 25 appearances with his latest in the last round against Cardiff. Taylor has started half of the Reds league games this season but is the leading goalscorer with five goals in all competitions. His all-round centre forward play is what makes him so lethal. The Monserrat international has excellent hold up ability and rarely misses a one-on-one opportunity which is something Cooper's side needs to be aware of.
The two sides last met in November 2020 at the City Ground with Connor Roberts scoring the only goal to secure a 1-0 win. However, over the last five meetings, it is Forest who have the advantage. The Reds have won twice, with the Swans winning just the once in the previous meeting. Under former boss Sabri Lamouchi, Forest won the last fixture at the Liberty thanks to a 90th minute winner from Alfa Semedo.
Last time out.....
How to watch
Due to the current national lockdown, no fans will be in attendance at The Liberty Stadium. However, the game will be live on BT Sport Extra 4 HD.
The game kicks off at 3:00 BST on Saturday 23 January 2021.