After failing to score in their last four league games, it was crucial for Jurgen Klopp's men to take all three points, as they seek to defend their crown.
While Spurs' own title ambitions were dented weeks ago, this loss serves as a further set-back in a title-race that looks impossible to call.
Jose Mourinho will be disappointed in the manner his side performed, particularly in the second-half where Tottenham looked out of ideas.
To rub salt into the wounds, it is reported that Harry Kane will be ruled out for the weeks to come, as he suffered an ankle injury in the first half.
The result meant Liverpool remained in fourth spot, while Spurs dropped into sixth, four points off the reds - albeit with a game in hand.
Individual errors write the script
In a game of such magnitude, there is no room for mistakes, to take all three points, players must be performing at their peak and that wasn't the case on Thursday night.
Very unlike the recent performances we have seen from Mourinho's men in big matches, Spurs looked exposed, struggling defensively with the Liverpool front three getting joy in behind.
Captain Lloris was also at fault for the second, parrying a shot straight into the path of Trent Alexander-Arnold who speared it home from close range.
Despite pulling one back with a brilliant strike from Pierre-Emile Hojbjerg, the two goal advantage was restored when Joe Rodon was hesitant in dealing with a cross, allowing Saido Mane to capitalise.
Defensive mistakes are not often associated with Mourinho sides, especially in games of this calibre so there is no doubt we will see some changes in the upcoming matches as the inquest begins.
Liverpool score some goals
Prior to this game, Liverpool had failed to score a league goal in 2021, a run that involved four straight games and 438 minutes of football.
In fact, they were one of only two teams in Europe's top five leagues to fail to register a league goal this season.
It will have come as a relief, to see both Mane and Firmino on the scoresheet for Klopp, while Mohamed Salah could have also had one had it not been for a handball in the build-up.
Surprisingly, the game had an end-to-end dynamic, giving the feel of a cup game as opposed to a league game, with Liverpool bossing territorial possession.
They created a whole host of chances which has been a key factor in their recent goal drought, looking back to their usual best.
Klopp will be hoping his side can build on the victory as they look to put pressure on both Manchester clubs over the course of the season.
Tottenham talisman Harry Kane was forced off at the interval after suffering an ankle injury in the first-half, the physio gave him treatment on two occasions but he never returned for the second-half.
Kane has been in terrific form over the course of this campaign, being involved in 33 goals in 29 appearances in all competitions this season.
In the Premier League he has recorded 12 goals and 11 assists in just 19 appearances, breaking Fabregas' record for the shortest time taken to reach double figure goals and assists.
He has also formed a special partnership with team-mate Heung-Min Son, with the pair equalling Chris Sutton and Alan Shearer's link-up record so early in the season.
Injuries have been a regular occurrence in the Englishman's career, with him missing large chunks of recent seasons, he is central to the system at Spurs and his unavailability will be a big miss.
It was reported both ankles were swollen following the match, having suffered injuries to that area before, there were fears he could be set for a lengthy spell on the sidelines, however, it is suggested the injury is not as serious as originally feared.