Tottenham came into the tie as favorites to come out on top, especially after winning Group J of the European competition scoring 15 goals.
Heung Min Son, Gareth Bale, Lucas Moura and Carlos Vinicius were the goalscorers for Jose Mourinho's side, who dominated the game from start to finish, having 62% of ball possession.
The victory against Wolfsberger AC, is the first ever away win for Tottenham Hotspur in the UEFA Europa League knock-out stages.
Room To Improve
Although they showed an impressive performance, Spurs still need to keep improving.
Midfielder, Moussa Sissoko, gave away a penalty to start the final 45 minutes, which Michael Lindl would score to put some pressure on the second leg for the Lilywhites.
Sissoko has been a man of trust for Jose Mourinho across all competitions, making appearances in 20 out of the 35 games Tottenham has played this season.
Not taking any risks
Despite being favorites to win, Jose Mourinho did not want any type of surprises in the game.
Harry Kane, who played against Everton in the FA Cup and Manchester City in the Premier League last week, did not make the trip with the team, but the Portuguese manager made sure to have enough firepower on the traveling squad.
On paper it was an easy fixture for Spurs, but to make sure the team lived up to the expectations, Jose Mourinho decided to start Lucas, Son, Bale and Dele Alli.
By scoring the final goal of the night, Vinicius recorded yet another goal in the UEFA Europa League, bringing his total to four goals and three assists in six games played.
Academy players, Dane Scarlett, Marcel Lavinier and Jamie Bowden were in the bench for Spurs but did not see any minutes.
Jose Mourinho's words
"I think we have one foot in the next round," 'Mou' said after the match. "I liked the performance in the first half. The performance in the second half gave them a little bit of self esteem."