Manchester City fell short to the hands of rivals, Manchester United, as a penalty and a Luke Shaw finessed finish saw the Red Devils end City's winning run of 21 consecutive games.
Instead, United increased their unbeaten away run to 22 league games.
On the night where City's dominance was brought to an end, here are the City players that stood out on the night, whether that be for positive or negative reasons:
Despite the outcome of another tense derby, Mahrez, was arguably Manchester City's strongest attacking threat throughout the game, causing Shaw and Aaron Wan-Bissaka issues for the majority of the game.
The 2016 BBC African Footballer of the Year had Shaw on strings, bursting into the box on multiple occasions but had no real options in the penalty area to put the ball on a plate for.
The Algerian has recently hit a rich vein of form, with four of his 11 total goal contributions in the Premier League coming in the last five games. He has struggled to make an impact since his hat-trick against Burnley in gameweek 10.
Although struggling to make the intended impact so far this season, Pep Guardiola's recent faith in the winger has paid off. However, even the in-form Mahrez was able to stamp his mark on the Manchester derby.
Sunday was just not Jesus' day. It all started after 34 seconds when the Brazilian brought down Anthony Martial in the box, giving Bruno Fernandes the chance to put United ahead in the opening stages; the Portuguese obliged.
As well as gifting United the opening goal, the striker was almost non-existent throughout the match, while Sergio Agüero watched from the bench in a game that would have been perfect for the Argentine.
Jesus' up-and-down season will be a worry for City fans, especially with Agüero yet to sign a contract extension at the club. Rumours about Erling Haaland will bring comfort to the fans, but the Brazilian's lack of threat in front of goal will be a concern for the future if Guardiola keeps his faith in the 23-year-old.
Jesus has only tallied up six league goals this season, with four of those coming in the last nine games. The Brazilian will need to make a comeback from a poor season if he is to keep his place in this City side, with Raheem Sterling, Bernardo Silva and Mahrez also able to play upfront.
Despite shipping two goals against United, the City keeper boasts the highest player rating out of any of the Citizens, which says more about the rest of the squad than it says about Ederson.
Ederson managed to get a hand to a Bruno Fernandes' penalty but was unable to push it away, with Shaw's strike into the far corner gave him absolutely no chance on the 50-minute mark.
Martial had the perfect chance to make it three to United, only for Ederson to pounce on what should have been an easy finish for the Frenchman, who eventually won Man of the Match.
In all competitions, Ederson has only conceded 19 goals and has kept 20 clean sheets - a very impressive stat to have kept more clean sheets than concede goals.
The dominance of Ruben Dias and John Stones has obviously made a massive impact, but that makes Ederson's performances all the more impressive with the keeper having to stay switched on during long spells of City possession.